Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL8991321 | 0.88 | TSHR (0.42) | MEN1TSHRKMT2APTGS1PDE4A | |
| SCHEMBL29857626 | 0.88 | PTGS1 (0.42) | PTGS1PDE4A | |
| Piperazine SCHEMBL28077828 | 0.86 | TSHR (0.41) | MEN1TSHRKMT2APTGS1PDE4A | |
| Aziridine SCHEMBL29141899 | 0.85 | TSHR (0.43) | MEN1TSHRKMT2APTGS1PDE4A | |
| Piperazine SCHEMBL28182579 | 0.84 | TSHR (0.39) | MEN1TSHRKMT2APTGS1PDE4A | |
| Piperazine SCHEMBL28675666 | 0.82 | TSHR (0.36) | MEN1TSHRKMT2APTGS1PDE4A | |
| Piperazine SCHEMBL28475479 | 0.79 | KDM4E (0.35) | MEN1TSHRKMT2A | |
| Piperidine SCHEMBL4434690 | 0.78 | ALDH1A1 (0.39) | MEN1TSHRKMT2APTGS1PDE4A | |
| Piperazine SCHEMBL29137239 | 0.75 | APP (0.41) | MEN1TSHRKMT2APTGS1PDE4A | |
| SCHEMBL30712101 | 0.74 | LMNA (0.42) | PTGS1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117987889-A | Additive for producing high-tensile high-elongation lithium electric copper foil and application thereof | 九江德福科技股份有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-117089899-A | Additive for direct-current deposition nano twin crystal copper foil and preparation method thereof | 九江德福科技股份有限公司 | 2023-11-21 | — | — | CN | disclosed |