Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28681663 | 0.86 | HPGD (0.56) | HPGDKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL28655780 | 0.86 | MAPK1 (0.56) | HPGDKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL28660619 | 0.84 | HPGD (0.53) | HPGDKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL21952060 | 0.84 | KMT2A (0.58) | HPGDKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL31396269 | 0.84 | KMT2A (0.58) | HPGDKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL28980860 | 0.82 | HPGD (0.46) | HPGDKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL28929896 | 0.81 | ALDH1A1 (0.53) | HPGDKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL21952006 | 0.78 | HPGD (0.47) | HPGDKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL30278755 | 0.78 | HPGD (0.47) | HPGDKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL28673393 | 0.77 | ALDH1A1 (0.41) | HPGDKMT2AMEN1NPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768422-A | Ubiquitin ligase inhibitors for the treatment of cancer | 诺沃亚桑托斯教授基金会 | 2023-03-07 | — | — | CN | disclosed |
| CN-113677340-A | Compounds that selectively and efficiently inhibit Hakai-mediated ubiquitination as anti-cancer agents | 诺沃亚桑托斯教授基金会 | 2021-11-19 | — | — | CN | disclosed |