Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28655780 | 0.88 | MAPK1 (0.56) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL28676728 | 0.86 | HPGD (0.53) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL28660619 | 0.86 | HPGD (0.53) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL28929896 | 0.84 | ALDH1A1 (0.53) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL21952070 | 0.83 | MEN1 (0.61) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL31396394 | 0.83 | MEN1 (0.61) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL21951990 | 0.77 | HPGD (0.50) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL30278744 | 0.77 | HPGD (0.50) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL28980860 | 0.74 | HPGD (0.46) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL28666198 | 0.74 | ALDH1A1 (0.43) | HPGDKMT2AMEN1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768422-A | Ubiquitin ligase inhibitors for the treatment of cancer | 诺沃亚桑托斯教授基金会 | 2023-03-07 | — | — | CN | disclosed |
| CN-113677340-A | Compounds that selectively and efficiently inhibit Hakai-mediated ubiquitination as anti-cancer agents | 诺沃亚桑托斯教授基金会 | 2021-11-19 | — | — | CN | disclosed |