Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28693254 | 0.85 | NR1H2 (0.49) | SMN1; SMN2HTTNPSR1NAMPT | |
| SCHEMBL19212238 | 0.83 | MAPT (0.42) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL19212239 | 0.81 | MAPT (0.57) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL19212456 | 0.81 | SMN1; SMN2 (0.52) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL31715873 | 0.80 | NAMPT (0.64) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL5573222 | 0.77 | MAPT (0.76) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL12676600 | 0.77 | MAPT (0.58) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL5462598 | 0.77 | GPR119 (0.58) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL30366165 | 0.75 | GPR119 (0.56) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4206232 | 0.75 | EPHX1 (0.63) | MAPTLMNAALDH1A1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-B1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | VALO HEALTH INC (US) | 2022-07-06 | — | — | EP | disclosed |
| CN-109071560-B | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | 瓦洛健康公司 | 2022-01-14 | — | — | CN | disclosed |