SCHEMBL4206232

SCHEMBL4206232

CC(C)(C)OC(=O)N1CCC(NC(=O)CCl)CC1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.63
EPHX2 P34913 3/20 0.50
L3MBTL1 Q9Y468 2/20 0.49
ALDH1A1 P00352 3/20 0.49
NPC1 O15118 1/20 0.48
MAPT P10636 1/20 0.48
MAPK1 P28482 1/20 0.48
HTT P42858 1/20 0.48
RAB9A P51151 1/20 0.48
HPGD P15428 1/20 0.48
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA9 Q16790 1/20 0.46
RECQL P46063 1/20 0.46
HDAC4 P56524 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
PTPN2 P17706 1/20 0.45
PTPN1 P18031 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18632877 0.92 EPHX1 (0.53) EPHX1HDAC4PARP1
SCHEMBL5118879 0.92 EPHX1 (0.53) EPHX1HDAC4PARP1
SCHEMBL30505540 0.92 EPHX1 (0.53) EPHX1HDAC4PARP1
SCHEMBL28495575 0.89 EPHX1 (0.60) EPHX1EPHX2L3MBTL1ALDH1A1NPC1
SCHEMBL2321232 0.87 EPHX1 (0.65) EPHX1EPHX2L3MBTL1ALDH1A1NPC1
SCHEMBL10268244 0.87 EPHX1 (0.65) EPHX1EPHX2L3MBTL1ALDH1A1NPC1
SCHEMBL22720466 0.86 EPHX1 (0.58) EPHX1EPHX2L3MBTL1ALDH1A1NPC1
SCHEMBL13459878 0.85 EPHX1 (0.63) EPHX1EPHX2L3MBTL1ALDH1A1NPC1
SCHEMBL307482 0.85 EPHX1 (0.63) EPHX1EPHX2L3MBTL1ALDH1A1NPC1
SCHEMBL25245907 0.85 NR1H2 (0.48) EPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2025-02-25 US disclosed
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-10-24 US disclosed
US-20240043441-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-02-08 US disclosed
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2024-01-23 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230234923-A1 USING ADIPONECTIN RECEPTOR AGONISTS TO TREAT INFLAMMATION AND BONE DISEASES IN DIABETES TRUSTEES OF TUFTS COLLEGE 2023-07-27 US disclosed
US-20230234923-A1 USING ADIPONECTIN RECEPTOR AGONISTS TO TREAT INFLAMMATION AND BONE DISEASES IN DIABETES TRUSTEES OF TUFTS COLLEGE 2023-07-27 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed
US-20110159019-A1 2,4-DIAMINOPYRIMIDINE COMPOUND ASTELLAS PHARMA INC. (JP) 2011-06-30 US disclosed
US-20110159019-A1 2,4-DIAMINOPYRIMIDINE COMPOUND ASTELLAS PHARMA INC. (JP) 2011-06-30 US disclosed
US-20090023733-A1 Piperidine Derivatives, Their Process for Preparation, Their Use as Therapeutic Agents and Pharmaceutical Compositions Containing Them ASTRAZENECA AB (SE) 2009-01-22 US disclosed
US-20080300232-A1 N-Piperidine Derivatives as Ccr3 Modulators ASTRAZENECA AB (SE) 2008-12-04 US disclosed
EP-1994002-A1 PIPERIDINE DERIVATIVES, THEIR PROCESS FOR PREPARATION, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AstraZeneca AB (SE) 2008-11-26 EP disclosed
WO-2007102767-A1 PIPERIDINE DERIVATIVES, THEIR PROCESS FOR PREPARATION, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ASTRAZENECA AB (SE) 2007-09-13 WO disclosed
EP-1730136-A1 N-PIPERIDINE DERIVATES AS CCR3 MODULATORS AstraZeneca AB (SE) 2006-12-13 EP disclosed
WO-2005090330-A1 N-PIPERIDINE DERIVATES AS CCR3 MODULATORS ASTRAZENECA AB (SE) 2005-09-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C KRAS, NRAS, HRAS EPHX1 4209/4885EPHX2 4171/4885L3MBTL1 1621/4885
US-20230234923-A1 USING ADIPONECTIN RECEPTOR AGONISTS TO TREAT INFLAMMATION AND BONE DISEASES IN DIABETES ADIPOR1, ADIPOR2, GPR119 EPHX1 1710/4885EPHX2 2083/4885L3MBTL1 4623/4885
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS EPHX1 3171/4885EPHX2 3027/4885L3MBTL1 561/4885
US-20090023733-A1 Piperidine Derivatives, Their Process for Preparation, Their Use as Therapeutic Agents and Pharmaceutical Compositions Containing Them CCR3, CCR1, CCR5 EPHX1 926/4885EPHX2 1167/4885L3MBTL1 4872/4885
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EPHX1 3171/4885EPHX2 3027/4885L3MBTL1 561/4885
US-20150239900-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EPHX1 1931/4885EPHX2 1887/4885L3MBTL1 424/4885
US-20230212183-A9 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EPHX1 1931/4885EPHX2 1887/4885L3MBTL1 424/4885
US-20080300232-A1 N-Piperidine Derivatives as Ccr3 Modulators CCR3, CCR1, CCR4 EPHX1 1340/4885EPHX2 2780/4885L3MBTL1 3275/4885
US-20240043441-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EPHX1 1931/4885EPHX2 1887/4885L3MBTL1 424/4885
US-20110159019-A1 2,4-DIAMINOPYRIMIDINE COMPOUND PRKCZ, DCLK1, AAK1 EPHX1 1872/4885EPHX2 2166/4885L3MBTL1 4296/4885
US-20230303586-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EPHX1 1931/4885EPHX2 1887/4885L3MBTL1 424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.