Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28707329 | 0.99 | PDGFRB (0.43) | PDGFRBPDGFRAPARP10S1PR1MKNK1 | |
| SCHEMBL30253716 | 0.96 | PARP10 (0.42) | PDGFRBPDGFRAPARP10S1PR1MKNK1 | |
| SCHEMBL28685072 | 0.96 | PARP10 (0.42) | PDGFRBPDGFRAPARP10S1PR1MKNK1 | |
| SCHEMBL28707299 | 0.81 | PARP10 (0.48) | PARP10MAP4K4PARP15 | |
| SCHEMBL28644569 | 0.73 | SIRT6 (0.51) | MKNK1MKNK2MAP4K4 | |
| SCHEMBL28698965 | 0.72 | SIRT6 (0.33) | — | |
| SCHEMBL30253497 | 0.72 | SIRT6 (0.33) | — | |
| SCHEMBL28685074 | 0.71 | MAPT (0.39) | PARP10MKNK1MKNK2 | |
| SCHEMBL28691237 | 0.71 | IKBKB (0.39) | MKNK1MKNK2LOXABL1 | |
| SCHEMBL30253592 | 0.71 | IKBKB (0.39) | MKNK1MKNK2LOXABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113336713-A | Preparation method of alkoxy pyrazine derivative and alkoxy pyrazine derivative | 中国人民解放军军事科学院军事医学研究院 | 2021-09-03 | — | — | CN | claimed |
| CN-113336713-B | Preparation method of alkoxy pyrazine derivative and alkoxy pyrazine derivative | 中国人民解放军军事科学院军事医学研究院 | 2023-03-17 | — | — | CN | disclosed |
| CN-113336713-A | Preparation method of alkoxy pyrazine derivative and alkoxy pyrazine derivative | 中国人民解放军军事科学院军事医学研究院 | 2021-09-03 | — | — | CN | disclosed |