Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | PAK4 | O96013 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3512392 | 0.82 | JAK2 (0.58) | NTRK1GSK3BCDC7JAK2ROCK2 | |
| SCHEMBL13375276 | 0.78 | MAP2K4 (0.49) | NTRK1JAK2PDPK1FGFR1MAPKAPK2 | |
| SCHEMBL17871939 | 0.76 | KDM4E (0.58) | NTRK1HAO1GABRA1GABRB2 | |
| SCHEMBL2574384 | 0.76 | TTK (0.55) | NTRK1 | |
| SCHEMBL2570073 | 0.76 | NTRK1 (0.42) | NTRK1JAK2ROCK2KDRMKNK2 | |
| SCHEMBL2557897 | 0.74 | TTK (0.60) | ITKJAK2KDRAKT1MAPK8 | |
| SCHEMBL16025864 | 0.74 | NTRK1 (0.59) | NTRK1ITKCDC7MAP4K4CDK2 | |
| SCHEMBL29693067 | 0.73 | MEN1 (0.53) | IDH1CALM1GABRA1GABRB2 | |
| SCHEMBL6583054 | 0.72 | PARP1 (0.49) | NTRK1GSK3BITKCDC7JAK2 | |
| SCHEMBL6586654 | 0.72 | PARP1 (0.46) | NTRK1GSK3BITKCDC7JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114072387-B | Indazole compound, pharmaceutical composition and application thereof | 暨南大学 | 2024-03-08 | — | — | CN | disclosed |
| EP-4056558-A1 | INDAZOLE COMPOUND, PHARMACEUTICAL COMPOSITION OF SAME, AND APPLICATIONS THEREOF | Jinan University (CN) | 2022-09-14 | — | — | EP | disclosed |
| US-20220281821-A1 | INDAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL COMPOSITIONS | JINAN UNIVERSITY (CN) | 2022-09-08 | — | — | US | disclosed |
| CN-114072387-A | Indazole compound and medicinal composition and application thereof | 暨南大学 | 2022-02-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220281821-A1 | INDAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL COMPOSITIONS | TNK2, TNNI3K, CSNK1G3 | NTRK1 63/4885GSK3B 34/4885ITK 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.