Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28686154 | 0.76 | NTRK1 (0.45) | NTRK1KDRCHEK2ROCK2JAK2 | |
| SCHEMBL3459871 | 0.72 | MAPK8 (0.46) | PARP1KDM4EALDH1A1LMNATSHR | |
| SCHEMBL17871939 | 0.72 | KDM4E (0.58) | NTRK1KDM4EALDH1A1LMNATSHR | |
| SCHEMBL14863667 | 0.71 | MAP2K4 (0.51) | TSHRCHEK2JAK2JAK1MAP2K4 | |
| SCHEMBL13375276 | 0.71 | MAP2K4 (0.49) | NTRK1PARP1JAK2MAP2K4 | |
| SCHEMBL28177161 | 0.70 | TBXA2R (0.54) | KDM4EALDH1A1LMNATSHRCHEK2 | |
| SCHEMBL2363976 | 0.70 | ALDH1A1 (0.46) | PARP1KDM4EALDH1A1LMNATSHR | |
| SCHEMBL2557897 | 0.69 | TTK (0.60) | KDRJAK2JAK1 | |
| SCHEMBL3461063 | 0.69 | TBXA2R (0.55) | KDM4EALDH1A1LMNATSHRAURKA | |
| SCHEMBL1004028 | 0.69 | TSHR (0.58) | KDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |