Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | RAB9A | P51151 | 6/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | CTSG | P08311 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876752 | 0.85 | NPC1 (0.52) | NPC1RAB9AEGFRPTGS2 | |
| SCHEMBL2878159 | 0.79 | NPC1 (0.53) | NPC1RAB9AATML3MBTL1SMPD1 | |
| SCHEMBL15742990 | 0.75 | CTSD (0.56) | NPC1RAB9AL3MBTL1SMPD1HDAC1 | |
| SCHEMBL29930887 | 0.75 | CTSD (0.56) | NPC1RAB9AL3MBTL1SMPD1HDAC1 | |
| SCHEMBL2875409 | 0.75 | ALDH1A1 (0.57) | NPC1RAB9AHDAC1HDAC8HDAC6 | |
| SCHEMBL7614854 | 0.74 | NPC1 (0.70) | NPC1RAB9AATML3MBTL1PTGS2 | |
| SCHEMBL4805215 | 0.73 | RAB9A (0.83) | NPC1RAB9AHDAC1HDAC8HDAC6 | |
| SCHEMBL12900956 | 0.73 | RAB9A (0.64) | NPC1RAB9AATML3MBTL1EGFR | |
| SCHEMBL2871475 | 0.73 | RAB9A (0.76) | NPC1RAB9ASMPD1HDAC1HDAC8 | |
| SCHEMBL536099 | 0.72 | CA12 (0.55) | PTGS2HPGDKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |