SCHEMBL536099

SCHEMBL536099

COc1ccc(O)cc1C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.55
CA1 P00915 3/20 0.55
CA2 P00918 3/20 0.55
CA7 P43166 3/20 0.55
CA9 Q16790 3/20 0.55
CA14 Q9ULX7 3/20 0.55
ALOX5 P09917 1/20 0.55
PTGS2 P35354 1/20 0.55
ALDH1A1 P00352 7/20 0.55
KDM4E B2RXH2 4/20 0.55
MAPT P10636 3/20 0.55
TDP1 Q9NUW8 2/20 0.55
HPGD P15428 1/20 0.55
LCK P06239 1/20 0.53
FYN P06241 1/20 0.53
SIRT1 Q96EB6 1/20 0.53
ABL1 P00519 1/20 0.52
RIN1 Q13671 1/20 0.52
MYC P01106 1/20 0.51
PTPN1 P18031 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL901018 0.84 ALDH1A1 (0.65) CA12CA1CA2CA7CA9
SCHEMBL503802 0.84 POLB (0.70) CA12CA1CA2CA7CA9
SCHEMBL563973 0.84 ALDH1A1 (0.56) CA12CA1CA2CA7CA9
SCHEMBL9185042 0.82 POLB (0.68) CA12CA1CA2CA7CA9
SCHEMBL9021036 0.82 SIRT1 (0.51) CA12CA1CA2CA7CA9
SCHEMBL12509335 0.82 SIRT1 (0.51) CA12CA1CA2CA7CA9
SCHEMBL7619139 0.82 CA12 (0.67) CA12CA1CA2CA7CA9
SCHEMBL31009365 0.82 CA12 (0.67) CA12CA1CA2CA7CA9
SCHEMBL9314517 0.82 CA12 (0.57) CA12CA1CA2CA7CA9
SCHEMBL91954 0.82 CSNK2A1 (0.59) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12076316-B2 Levorphanol prodrugs and processes for making and using them ZEVRA THERAPEUTICS INC. 2024-09-03 US claimed
US-20220096463-A1 LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM ALTER DOMUS (US) LLC 2022-03-31 US claimed
US-11234975-B2 Levorphanol prodrugs and processes for making and using them KEMPHARM, INC. (US) 2022-02-01 US claimed
US-20200390757-A1 LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM ALTER DOMUS (US) LLC 2020-12-17 US claimed
WO-2018191474-A1 LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM KEMPHARM, INC. (US) 2018-10-18 WO claimed
US-20170312270-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF ALTER DOMUS (US) LLC 2017-11-02 US claimed
EP-3226907-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS AND MAKING AND USE THEREOF Kempharm, Inc. (US) 2017-10-11 EP claimed
EP-3223819-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYCODONE Kempharm, Inc. (US) 2017-10-04 EP claimed
US-20160168160-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF ALTER DOMUS (US) LLC 2016-06-16 US claimed
WO-2016089951-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS AND MAKING AND USE THEREOF KEMPHARM, INC. (US) 2016-06-09 WO claimed
EP-2771002-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF Kempharm, Inc. (US) 2014-09-03 EP claimed
EP-2736510-A2 METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME Kempharm, Inc. (US) 2014-06-04 EP claimed
CN-103826633-A Methylphenidate prodrugs, methods of making and using the same KEMPHARM INC 2014-05-28 CN claimed
US-20130150395-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF KEMPHARM, INC. (US) 2013-06-13 US claimed
WO-2013063204-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF KEMPHARM, INC. (US) 2013-05-02 WO claimed
WO-2013016668-A2 METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME KEMPHARM INC. (US) 2013-01-31 WO claimed
US-20120142719-A1 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof ALTER DOMUS (US) LLC 2012-06-07 US claimed
CN-102480959-A Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof KEMPHARM INC 2012-05-30 CN claimed
EP-2448407-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF Kempharm, Inc. (US) 2012-05-09 EP claimed
US-20110002990-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF ALTER DOMUS (US) LLC 2011-01-06 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200390757-A1 LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM OPRM1, OPRL1, OPRK1 CA12 1814/4885CA1 1503/4885CA2 3018/4885
US-20170312270-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF OPRM1, OPRK1, OPRD1 CA12 1883/4885CA1 1451/4885CA2 1603/4885
US-12076316-B2 Levorphanol prodrugs and processes for making and using them OPRM1, OPRL1, OPRK1 CA12 1814/4885CA1 1503/4885CA2 3018/4885
US-20160168160-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF OPRM1, OPRK1, OPRD1 CA12 1805/4885CA1 1873/4885CA2 1693/4885
US-11234975-B2 Levorphanol prodrugs and processes for making and using them OPRM1, OPRL1, OPRK1 CA12 1814/4885CA1 1503/4885CA2 3018/4885
US-20110002990-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF CYP2B6, CYP3A43, CYP2D6 CA12 2215/4885CA1 1685/4885CA2 1960/4885
US-20120142719-A1 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof CYP2B6, CYP3A43, CYP2D6 CA12 2215/4885CA1 1685/4885CA2 1960/4885
US-20130150395-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF OPRM1, OPRK1, CYP2D6 CA12 1872/4885CA1 1329/4885CA2 2379/4885
US-20220096463-A1 LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM OPRM1, OPRL1, OPRK1 CA12 1814/4885CA1 1503/4885CA2 3018/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.