Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22580604 | 0.88 | NR1H4 (0.56) | NR1H4ABCB1KMT2AGAAHSD17B10 | |
| SCHEMBL9435244 | 0.86 | CHRNA1 (0.50) | NR1H4ABCB1KMT2AGAAHSD17B10 | |
| SCHEMBL9435248 | 0.86 | CHRNA1 (0.50) | NR1H4ABCB1KMT2AGAAHSD17B10 | |
| SCHEMBL25970079 | 0.82 | TAS1R3 (0.56) | NR1H4ABCB1KMT2AGAAHSD17B10 | |
| SCHEMBL14339243 | 0.81 | SMPD1 (0.48) | ABCB1KMT2AGAAHSD17B10TAS1R3 | |
| SCHEMBL24386356 | 0.81 | LMNA (0.56) | KMT2AGAAHPGDLMNAPOLB | |
| SCHEMBL9717443 | 0.81 | GAA (0.77) | KMT2AGAAHSD17B10HPGDSMPD1 | |
| SCHEMBL5800429 | 0.81 | LMNA (0.56) | KMT2AGAAHPGDLMNAPOLB | |
| SCHEMBL22580603 | 0.80 | KMT2A (0.69) | NR1H4KMT2ATAS1R3TAS1R1TP53 | |
| SCHEMBL19291298 | 0.80 | NPC1 (0.68) | NR1H4KMT2ATP53LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144906-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-12-05 | — | — | US | disclosed |
| US-7030143-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-04-18 | — | — | US | disclosed |
| US-7022723-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-04-04 | — | — | US | disclosed |
| EP-1634876-A2 | Heterocyclic compounds for the treatment of hyperlipidemia agents | Nippon Shinyaku Co., Ltd. (JP) | 2006-03-15 | — | — | EP | disclosed |
| US-6998412-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-02-14 | — | — | US | disclosed |
| US-20050009785-A1 | Heterocyclic compounds | KUWABARA KENJI (JP) | 2005-01-13 | — | — | US | disclosed |
| US-20050009892-A1 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2005-01-13 | — | — | US | disclosed |
| US-20040162325-A1 | Heterocyclic compounds | KUWABARA KENJI (JP) | 2004-08-19 | — | — | US | disclosed |
| US-20030166697-A1 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2003-09-04 | — | — | US | disclosed |
| EP-1295875-A1 | HETEROCYCLIC COMPOUNDS | Nippon Shinyaku Co., Ltd. (JP) | 2003-03-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009785-A1 | Heterocyclic compounds | LIPC, GPR119, APOB | NR1H4 479/4885ABCB1 839/4885KMT2A 1723/4885 |
| US-20050009892-A1 | Heterocyclic compounds | GPR119, LIPC, LIPE | NR1H4 612/4885ABCB1 820/4885KMT2A 2137/4885 |
| US-20040162325-A1 | Heterocyclic compounds | LIPE, GPR119, LIPC | NR1H4 597/4885ABCB1 1038/4885KMT2A 2456/4885 |
| US-20030166697-A1 | Heterocyclic compounds | LIPE, GPR119, LIPC | NR1H4 597/4885ABCB1 1038/4885KMT2A 2456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.