SCHEMBL28689243

SCHEMBL28689243

NCCNCCc1ccc(O)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.61
ALDH1A1 P00352 1/20 0.61
HTR1A P08908 1/20 0.61
ADRA2A P08913 1/20 0.61
SLC6A2 P23975 1/20 0.61
CYP2C19 P33261 1/20 0.61
HTR3A P46098 1/20 0.61
BACE1 P56817 1/20 0.61
TAAR1 Q96RJ0 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
BLM P54132 1/20 0.59
KMT2A Q03164 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
SIGMAR1 Q99720 4/20 0.55
TMEM97 Q5BJF2 1/20 0.55
ESR1 P03372 1/20 0.52
ESR2 Q92731 1/20 0.52
CA2 P00918 2/20 0.51
CA1 P00915 1/20 0.51
F13A1 P00488 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5099658 0.90 ADRA2A (0.59) KDM4EALDH1A1HTR1AADRA2ASLC6A2
SCHEMBL7381628 0.89 TMEM97 (0.67) KDM4EALDH1A1HTR1AADRA2ASLC6A2
SCHEMBL1586939 0.88 ADRA2A (0.57) KDM4EALDH1A1HTR1AADRA2ASLC6A2
Trientine SCHEMBL29145946 0.84 CA12 (0.58) KDM4EALDH1A1HTR1AADRA2ASLC6A2
SCHEMBL6013974 0.82 CA1 (0.50) KDM4EALDH1A1HTR1AADRA2ASLC6A2
SCHEMBL29017807 0.81 CA2 (0.60) KDM4EALDH1A1HTR1AADRA2ASLC6A2
SCHEMBL18122725 0.81 OPRK1 (0.64) SLC6A2SIGMAR1TMEM97ADRB2BCHE
SCHEMBL28690750 0.81 CA1 (0.53) KDM4EALDH1A1HTR1AADRA2ASLC6A2
SCHEMBL7379754 0.80 ESR1 (0.60) KDM4EALDH1A1ADRA2ASLC6A2SIGMAR1
SCHEMBL7386235 0.79 SIGMAR1 (0.61) KDM4EALDH1A1ADRA2ASLC6A2SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110387035-B Demulsifier, preparation method thereof and application thereof in demulsification of thick oil containing asphaltene 中国石油化工股份有限公司 2022-01-04 CN disclosed