Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873354 | 0.93 | ALDH1A1 (0.52) | ALDH1A1ALOX5POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL3998593 | 0.88 | ALDH1A1 (0.50) | ALDH1A1ALOX5POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL2875353 | 0.88 | ALOX5 (0.55) | ALDH1A1ALOX5POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL2878276 | 0.88 | MAPT (0.48) | ALDH1A1ALOX5POLBSMN1; SMN2MAPT | |
| SCHEMBL2878351 | 0.86 | ALOX5 (0.55) | ALDH1A1ALOX5MAPT | |
| SCHEMBL2873169 | 0.85 | ACLY (0.51) | ALDH1A1ALOX5POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL2873564 | 0.83 | MAPT (0.44) | ALDH1A1ALOX5POLBMAPT | |
| SCHEMBL2878384 | 0.81 | MAPT (0.48) | ALDH1A1ALOX5MAPT | |
| SCHEMBL3998451 | 0.80 | ACLY (0.50) | ALDH1A1ALOX5SMN1; SMN2AKR1C3MAPT | |
| SCHEMBL2872278 | 0.80 | ACLY (0.51) | ALDH1A1ALOX5SMN1; SMN2AKR1C3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066628-B1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2010-10-20 | — | — | EP | disclosed |