SCHEMBL2875353

SCHEMBL2875353

COc1ccc(CCNS(=O)(=O)c2cc(-c3[nH]c4ccccc4c3CC(=O)O)ccc2Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.55
ALDH1A1 P00352 3/20 0.54
PPARG P37231 1/20 0.52
MAPT P10636 3/20 0.47
CYP19A1 P11511 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.45
AKR1C3 P42330 1/20 0.44
POLB P06746 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2878351 0.93 ALOX5 (0.55) ALOX5ALDH1A1PPARGMAPTCYP19A1
SCHEMBL2872278 0.92 ACLY (0.51) ALOX5ALDH1A1PPARGMAPTSMN1; SMN2
SCHEMBL2873034 0.91 MGAM (0.46) ALOX5PPARGMAPTPOLB
SCHEMBL2869092 0.88 ALDH1A1 (0.54) ALOX5ALDH1A1MAPTSMN1; SMN2AKR1C3
SCHEMBL2878384 0.88 MAPT (0.48) ALOX5ALDH1A1MAPT
SCHEMBL2876512 0.86 MAPT (0.51) ALOX5ALDH1A1MAPTCYP19A1SMN1; SMN2
SCHEMBL2873354 0.86 ALDH1A1 (0.52) ALOX5ALDH1A1MAPTSMN1; SMN2AKR1C3
SCHEMBL2875693 0.86 ALDH1A1 (0.46) ALOX5ALDH1A1PPARGMAPT
SCHEMBL3998593 0.85 ALDH1A1 (0.50) ALOX5ALDH1A1MAPTSMN1; SMN2AKR1C3
SCHEMBL2873463 0.85 ACLY (0.51) ALOX5ALDH1A1MAPTSMN1; SMN2AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2066628-B1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS SANOFI AVENTIS (FR) 2010-10-20 EP claimed
US-20090176804-A1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS SANOFI-AVENTIS (FR) 2009-07-09 US claimed
EP-2066628-A1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS Sanofi-Aventis (FR) 2009-06-10 EP claimed
WO-2008014186-A1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS SANOFI-AVENTIS (FR) 2008-01-31 WO claimed
EP-2066628-B1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS SANOFI AVENTIS (FR) 2010-10-20 EP disclosed
US-20090176804-A1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS SANOFI-AVENTIS (FR) 2009-07-09 US disclosed
US-20090176804-A1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS SANOFI-AVENTIS (FR) 2009-07-09 US disclosed
US-20090176804-A1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS SANOFI-AVENTIS (FR) 2009-07-09 US disclosed
EP-2066628-A1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS Sanofi-Aventis (FR) 2009-06-10 EP disclosed
WO-2008014186-A1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS SANOFI-AVENTIS (FR) 2008-01-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090176804-A1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS PTGER2, PTGDR2, CYSLTR2 ALOX5 171/4885ALDH1A1 1757/4885PPARG 1022/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.