Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.53 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | TACR3 | P29371 | 3/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28691066 | 0.88 | CYP3A4 (0.68) | RUVBL1CYP3A4TACR3MEN1KMT2A | |
| SCHEMBL28679435 | 0.86 | DHODH (0.47) | PLA2G2ARUVBL1CYP3A4CA9CA12 | |
| SCHEMBL28672796 | 0.85 | MCL1 (0.46) | PLA2G2A | |
| SCHEMBL28696167 | 0.81 | MCL1 (0.55) | PLA2G2ACYP3A4CA9CA12CA1 | |
| SCHEMBL1899842 | 0.79 | STAT3 (0.63) | PLA2G2ARUVBL1CYP3A4CA9CA12 | |
| SCHEMBL29290339 | 0.79 | DHODH (0.73) | PLA2G2ADHODHMEN1KMT2ANPC1 | |
| SCHEMBL28673422 | 0.77 | MEN1 (0.59) | RUVBL1CYP3A4TACR3MEN1KMT2A | |
| SCHEMBL28691059 | 0.77 | PLA2G2A (0.56) | PLA2G2ARUVBL1CYP3A4CA9CA12 | |
| SCHEMBL6309512 | 0.77 | DHODH (0.73) | PLA2G2ADHODHMEN1KMT2ANPC1 | |
| SCHEMBL1896811 | 0.77 | DHODH (0.72) | PLA2G2ADHODHMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113747920-A | Immune checkpoint inhibitor combination therapy using quinoline carboxamide derivatives | 株式会社益力多本社 | 2021-12-03 | — | — | CN | disclosed |
| CN-112703001-A | Combination cancer therapy using quinoline carboxamide derivatives | 株式会社益力多本社 | 2021-04-23 | — | — | CN | disclosed |