Malonic Acid

Malonic Acid

SCHEMBL28697215

CCCC(O)O.O=C(O)CC(=O)O

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LDHA P00338 1/20 0.47
SRR Q9GZT4 1/20 0.47
HDAC1 Q13547 2/20 0.46
HDAC2 Q92769 2/20 0.46
CHRM1 P11229 1/20 0.46
AKR1A1 P14550 1/20 0.46
CHRM3 P20309 1/20 0.46
HTR2A P28223 1/20 0.46
HTR2C P28335 1/20 0.46
ADRA1A P35348 1/20 0.46
HRH1 P35367 1/20 0.46
DRD3 P35462 1/20 0.46
SLC6A3 Q01959 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
HDAC8 Q9BY41 2/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
GPR84 Q9NQS5 7/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetoacetic Acid SCHEMBL9682963 0.88 HDAC1 (0.41) LDHASRRHDAC1HDAC2CHRM1
Acetoacetic Acid SCHEMBL2381598 0.88 HDAC1 (0.41) LDHASRRHDAC1HDAC2CHRM1
Propionic Acid SCHEMBL406808 0.86 FFAR3 (0.56) HDAC1HDAC2CHRM1AKR1A1CHRM3
Propionic Acid SCHEMBL28468420 0.86 FFAR3 (0.56) HDAC1HDAC2CHRM1AKR1A1CHRM3
Bicarbonate SCHEMBL14562444 0.86 HDAC1 (0.52) HDAC1HDAC2CHRM1AKR1A1CHRM3
Bicarbonate SCHEMBL10590002 0.86 HDAC1 (0.52) HDAC1HDAC2CHRM1AKR1A1CHRM3
Malonic Acid SCHEMBL28290691 0.85 GPR84 (0.47) LDHASRRGPR84FFAR1FFAR4
Succinic Acid SCHEMBL28438549 0.84 HDAC1 (0.52) HDAC1HDAC2CHRM1AKR1A1CHRM3
Succinic Acid SCHEMBL4667877 0.84 HDAC1 (0.52) HDAC1HDAC2CHRM1AKR1A1CHRM3
Succinic Acid SCHEMBL28210913 0.84 HDAC1 (0.52) HDAC1HDAC2CHRM1AKR1A1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113929574-B Method for preparing butanediol ester compound from tetrahydrofuran compound 中国科学院山西煤炭化学研究所 2024-02-02 CN disclosed
CN-116063654-A Oil-resistant thermoplastic polyurethane elastomer and preparation method and application thereof 万华化学集团股份有限公司 2023-05-05 CN disclosed
CN-113929574-A Method for preparing butanediol ester compounds from tetrahydrofuran compounds 中国科学院山西煤炭化学研究所 2022-01-14 CN disclosed