Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286951 | 0.84 | ALDH1A1 (0.37) | ALDH1A1MAPK1HIF1ANPC1KMT2A | |
| SCHEMBL287785 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2HPGDALDH1A1MAPK1HIF1A | |
| SCHEMBL287667 | 0.72 | ALDH1A1 (0.32) | SMN1; SMN2ALDH1A1MAPK1HIF1ANPC1 | |
| SCHEMBL9249536 | 0.71 | HPGD (0.57) | SMN1; SMN2HPGDALDH1A1MAPK1HIF1A | |
| SCHEMBL661273 | 0.69 | HPGD (0.43) | SMN1; SMN2HPGDALDH1A1MAPK1HIF1A | |
| SCHEMBL27573170 | 0.65 | KMT2A (0.54) | SMN1; SMN2HPGDALDH1A1MAPK1HIF1A | |
| SCHEMBL13715900 | 0.64 | ALDH1A1 (0.61) | SMN1; SMN2HPGDALDH1A1MAPK1HIF1A | |
| SCHEMBL15676231 | 0.64 | CA12 (0.54) | SMN1; SMN2HPGDALDH1A1NPC1KMT2A | |
| SCHEMBL30173802 | 0.63 | ALDH1A1 (0.62) | SMN1; SMN2HPGDALDH1A1MAPK1HIF1A | |
| SCHEMBL2258001 | 0.63 | ALDH1A1 (0.62) | SMN1; SMN2HPGDALDH1A1MAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427432-A2 | NOVEL HETEROCYCLIC COMPOUNDS | Torrent Pharmaceuticals Limited (IN) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128528-A2 | NOVEL HETEROCYCLIC COMPOUNDS | TORRENT PHARMACEUTICALS LIMITED (IN) | 2010-11-11 | — | — | WO | disclosed |