Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22831567 | 0.83 | NOTUM (0.69) | SMN1; SMN2P2RX7NOTUMPOLBLMNA | |
| SCHEMBL28697965 | 0.81 | NOTUM (0.55) | SMN1; SMN2P2RX7NOTUMPOLBLMNA | |
| SCHEMBL22831641 | 0.80 | ALDH1A1 (0.54) | SMN1; SMN2P2RX7NOTUMHTTALDH1A1 | |
| SCHEMBL22683783 | 0.79 | P2RX7 (0.48) | SMN1; SMN2P2RX7NOTUMPOLBHTT | |
| SCHEMBL22831699 | 0.79 | NOTUM (0.49) | SMN1; SMN2P2RX7NOTUMLMNAHTT | |
| SCHEMBL18490120 | 0.79 | POLB (0.40) | SMN1; SMN2P2RX7NOTUMPOLBLMNA | |
| SCHEMBL1801839 | 0.78 | RAB9A (0.49) | SMN1; SMN2P2RX7POLBLMNAMAPKAPK2 | |
| SCHEMBL22831606 | 0.77 | P2RX7 (0.49) | SMN1; SMN2P2RX7NOTUMHTTALDH1A1 | |
| SCHEMBL10983009 | 0.75 | SMN1; SMN2 (0.76) | SMN1; SMN2POLBALDH1A1TP53KDM4E | |
| SCHEMBL2238946 | 0.74 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBLMNAMAPKAPK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220259212-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-08-18 | — | — | US | disclosed |
| EP-3997083-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE | Idorsia Pharmaceuticals Ltd (CH) | 2022-05-18 | — | — | EP | disclosed |
| CN-114127066-A | Inhibitors of indoleamine 2, 3-dioxygenase and/or tryptophan 2, 3-dioxygenase | 爱杜西亚药品有限公司 | 2022-03-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259212-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE | IDO2, TDO2, IDO1 | SMN1; SMN2 4731/4885P2RX7 3759/4885NOTUM 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.