Sugi Predict

Sugi Predict / Compounds / SCHEMBL286994

SCHEMBL286994

SCHEMBL286994

COC(=O)Cc1ccc(O)c([N+](=O)[O-])c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.59
▸ GAA P10253 1/20 0.59
▸ GFER P55789 1/20 0.59
▸ POLB P06746 1/20 0.49
▸ MAPT P10636 4/20 0.48
▸ NPSR1 Q6W5P4 1/20 0.48
▸ MAPK1 P28482 2/20 0.47
▸ HSP90AB1 P08238 1/20 0.47
▸ TP53 P04637 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ GPR35 Q9HC97 1/20 0.47
▸ PDGFRB P09619 1/20 0.47
▸ FGFR1 P11362 1/20 0.47
▸ PDGFRA P16234 1/20 0.47
▸ FLT1 P17948 1/20 0.47
▸ FGFR3 P22607 1/20 0.47
▸ KDR P35968 1/20 0.47
▸ L3MBTL1 Q9Y468 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31170840 1.00 ALDH1A1 (0.59) ALDH1A1GAAGFERPOLBMAPT
SCHEMBL2435686 0.88 ALDH1A1 (0.55) ALDH1A1GAAGFERMAPTMAPK1
SCHEMBL5416433 0.85 POLB (0.50) ALDH1A1GAAGFERPOLBMAPT
SCHEMBL30201064 0.85 POLB (0.50) ALDH1A1GAAGFERPOLBMAPT
SCHEMBL1694828 0.85 MAPT (0.49) ALDH1A1POLBMAPTNPSR1MAPK1
SCHEMBL7984261 0.85 POLB (0.49) ALDH1A1GAAGFERPOLBMAPT
SCHEMBL16412469 0.85 PDGFRB (0.57) ALDH1A1GAAGFERMAPTMAPK1
SCHEMBL20045093 0.85 PDGFRB (0.53) ALDH1A1GAAGFERMAPTNPSR1
SCHEMBL9558321 0.84 POLB (0.46) ALDH1A1GAAGFERPOLBMAPT
SCHEMBL731999 0.84 MEN1 (0.56) ALDH1A1GAAGFERPOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109721586-B 5-benzyl-3-pyridyl-1H-1, 2, 4-triazole compound and preparation method and application thereof 中国医科大学 2021-03-02 — — CN claimed
CN-109721586-A A kind of 5- benzyl -3- pyridyl group -1H-1,2,4- triazole class compounds and its preparation method and application 中国医科大学 2019-05-07 — — CN claimed
EP-4721737-A1 USE OF PHARMACEUTICAL COMPOSITION COMPRISING COMPOUND HAVING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE FOR TREATING ANEMIA-RELATED DISEASES Scinnohub Pharmaceutical Co., Ltd. (CN) 2026-04-08 — — EP disclosed
US-12565492-B2 Anaplastic Lymphoma Kinase (ALK) degraders and uses thereof TRIANA BIOMEDICINES, INC. (US) 2026-03-03 — — US disclosed
US-20260042752-A1 ANAPLASTIC LYMPHOMA KINASE (ALK) DEGRADERS AND USES THEREOF TRIANA BIOMEDICINES INC (US) 2026-02-12 — — US disclosed
US-20250145635-A1 COMPOUND CONTAINING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE AND USE THEREOF IN MEDICINE SCINNOHUB PHARMACEUTICAL CO., LTD. (CN) 2025-05-08 — — US disclosed
WO-2024245143-A1 USE OF PHARMACEUTICAL COMPOSITION COMPRISING COMPOUND HAVING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE FOR TREATING ANEMIA-RELATED DISEASES 赛诺哈勃药业（成都）有限公司 2024-12-05 — — WO disclosed
EP-4455136-A1 COMPOUND CONTAINING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE AND USE THEREOF IN MEDICINE Scinnohub Pharmaceutical Co., Ltd. (CN) 2024-10-30 — — EP disclosed
US-RE49934-E1 Inhibitors of cellular metabolic processes SERVIER PHARMACEUTICALS LLC (US) 2024-04-23 — — US disclosed
EP-3573960-B1 N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES GENFIT (FR) 2023-08-16 — — EP disclosed
CN-116554050-A Amide phenol derivative and application thereof 四川大学 2023-08-08 — — CN disclosed
EP-0820441-A1 INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-01-28 — — EP disclosed
WO-1996032379-A1 INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-10-17 — — WO disclosed
US-4847269-A GLAUCOMA, AMIDES OR UREA DERIVATIVES OF AMINOETHYLCARBOXY COMPOUNDS SYNTEX (U.S.A.) INC. (US) 1989-07-11 — — US disclosed
US-4752621-A Arylalkyl amines useful for lowering intraocular pressure SYNTEX (U.S.A.) INC. (US) 1988-06-21 — — US disclosed
US-4642378-A Arylalkyl amines useful for lowering intraocular pressure SYNTEX (U.S.A.) INC. (US) 1987-02-10 — — US disclosed
US-4629730-A ADMINISTERING DIALKYL OR CYCLOAKYL AMINO ETHYLANILINE DERIVATIVES SYNTEX (U.S.A.) INC. (US) 1986-12-16 — — US disclosed
EP-0180994-A2 Antihypertensive dialkyl aminoethylaniline derivatives SYNTEX (U.S.A.) INC. (US) 1986-05-14 — — EP disclosed
EP-0081321-A1 2-Aminophenol derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 1983-06-15 — — EP disclosed
US-4016193-A ANALGESICS, ANTIINFLAMMATORY AGENTS MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JA) 1977-04-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250145635-A1 COMPOUND CONTAINING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE AND USE THEREOF IN MEDICINE BCL9, USP9X, BCL9L ALDH1A1 2611/4885GAA 380/4885GFER 2141/4885
US-20260042752-A1 ANAPLASTIC LYMPHOMA KINASE (ALK) DEGRADERS AND USES THEREOF ALK, NTRK1, NTRK3 ALDH1A1 2403/4885GAA 1685/4885GFER 3720/4885
US-12565492-B2 Anaplastic Lymphoma Kinase (ALK) degraders and uses thereof ALK, NTRK3, NTRK1 ALDH1A1 2387/4885GAA 2291/4885GFER 1722/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.