Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.58 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.58 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28563694 | 0.80 | KDM4E (0.47) | PI4KAPI4K2BPI4K2API4KBMAPT | |
| SCHEMBL1895948 | 0.76 | NPC1 (0.55) | PI4KAPI4K2BPI4K2API4KBMAPT | |
| SCHEMBL5024094 | 0.75 | MAPT (0.53) | PI4KAPI4K2BPI4K2API4KBMAPT | |
| SCHEMBL9175738 | 0.73 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL28700989 | 0.73 | PI4KA (0.62) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL56854 | 0.72 | RAB9A (0.55) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL8296009 | 0.72 | NOS2 (0.41) | PI4KAPI4K2BPI4K2API4KBMAPT | |
| SCHEMBL14629876 | 0.71 | PTGES (0.52) | — | |
| SCHEMBL27761849 | 0.70 | NPC1 (0.56) | PI4KAPI4K2BPI4K2API4KBMAPT | |
| SCHEMBL13504644 | 0.70 | NPC1 (0.50) | MAPTALDH1A1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010088574-A1 | AZABENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-08-05 | — | — | WO | disclosed |