Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | USP2 | O75604 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29044123 | 0.87 | ALDH1A1 (0.51) | TP53ALDH1A1MAPTUSP2ALOX15 | |
| SCHEMBL29044109 | 0.86 | ALDH1A1 (0.50) | TP53ALDH1A1MAPTUSP2ALOX15 | |
| SCHEMBL28693182 | 0.85 | TP53 (0.52) | TP53ALDH1A1MAPTUSP2ALOX15 | |
| SCHEMBL29044117 | 0.85 | ALDH1A1 (0.48) | TP53ALDH1A1MAPTUSP2ALOX15 | |
| SCHEMBL29044126 | 0.83 | ALDH1A1 (0.48) | TP53ALDH1A1MAPTUSP2ALOX15 | |
| SCHEMBL29044128 | 0.82 | MAPT (0.59) | TP53ALDH1A1MAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL29044127 | 0.81 | ALDH1A1 (0.62) | TP53ALDH1A1MAPTUSP2ALOX15 | |
| SCHEMBL29044121 | 0.79 | ALDH1A1 (0.51) | TP53ALDH1A1MAPTUSP2ALOX15 | |
| SCHEMBL28705159 | 0.75 | ALDH1A1 (0.55) | TP53ALDH1A1MAPTUSP2MAPK1 | |
| SCHEMBL24281187 | 0.74 | RAD52 (0.72) | TP53ALDH1A1MAPTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057626-B | Indole-2, 3-dione derivative, preparation method thereof and anti-liver cancer drug for inhibiting RECQL4 specific expression | 山东第一医科大学(山东省医学科学院) | 2023-06-30 | — | — | CN | disclosed |
| CN-114057626-A | Indole-2, 3-dione derivative, preparation method thereof and anti-liver cancer drug for inhibiting RECQL4 specific expression | 山东第一医科大学(山东省医学科学院) | 2022-02-18 | — | — | CN | disclosed |