SCHEMBL28706409

SCHEMBL28706409

Fc1cc(F)c2[nH]c3c(F)cc(F)cc3c2c1

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 1/20 0.48
DAO P14920 1/20 0.41
APOL1 O14791 6/20 0.36
GSK3A P49840 1/20 0.35
GSK3B P49841 1/20 0.35
AR P10275 1/20 0.34
TERT O14746 2/20 0.33
KCNH2 Q12809 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
HRH4 Q9H3N8 1/20 0.32
PGR P06401 1/20 0.32
METAP2 P50579 1/20 0.31
TGM2 P21980 1/20 0.31
CES2 O00748 1/20 0.31
CES1 P23141 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29507658 1.00 GPR84 (0.48) GPR84DAOAPOL1GSK3AGSK3B
SCHEMBL17950800 0.79 ALDH1A1 (0.48) ALDH1A1
SCHEMBL29936825 0.75 DAO (0.41) GPR84DAOAPOL1GSK3AGSK3B
SCHEMBL24408355 0.75 GPR84 (0.39) GPR84DAOAPOL1GSK3AGSK3B
SCHEMBL25206708 0.75 DAO (0.41) GPR84DAOAPOL1GSK3AGSK3B
SCHEMBL28906996 0.74 AR (0.41) GPR84ARALDH1A1PGR
SCHEMBL29548318 0.73 ACHE (0.63)
SCHEMBL22454062 0.73 GPR84 (0.44) GPR84DAOAPOL1TERTKCNH2
SCHEMBL20356023 0.72 GPR84 (0.41) GPR84ALDH1A1TGM2CES2CES1
SCHEMBL10067364 0.71 GPR84 (0.36) GPR84DAOAPOL1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114163379-A Fluorocarbazolyl diphenylethylene biphenyl compound and preparation method and application thereof 闽都创新实验室 2022-03-11 CN disclosed