Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28701609 | 0.89 | MAPT (0.53) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL28720669 | 0.87 | SMN1; SMN2 (0.51) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL29654116 | 0.87 | ACHE (0.56) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL28707179 | 0.87 | ACHE (0.56) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL4444299 | 0.80 | MAPT (0.49) | MAPTSMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL26319518 | 0.80 | ALDH1A1 (0.73) | MAPTSMN1; SMN2ALDH1A1KDM4EATM | |
| SCHEMBL25362033 | 0.78 | ALDH1A1 (0.51) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL30528155 | 0.78 | ALDH1A1 (0.51) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL10068462 | 0.78 | ADRB2 (0.57) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL10037335 | 0.78 | ALDH1A1 (0.51) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114249702-A | N-aryl- [2,4 '-bithiazole ] -2' -amine compound and preparation and application thereof | 沈阳药科大学 | 2022-03-29 | — | — | CN | disclosed |