SCHEMBL28709149

SCHEMBL28709149

CC(C)(C)c1cccc(C(=O)O)c1I

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.50
CA2 P00918 2/20 0.43
ALDH1A1 P00352 4/20 0.43
KDM4E B2RXH2 2/20 0.41
HPGD P15428 2/20 0.41
HSD17B10 Q99714 2/20 0.41
MAPT P10636 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
TAS2R14 Q9NYV8 1/20 0.40
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
PPARG P37231 1/20 0.38
NR1H4 Q96RI1 1/20 0.38
TSHR P16473 2/20 0.38
NR4A1 P22736 1/20 0.38
NR4A2 P43354 1/20 0.38
NR4A3 Q92570 1/20 0.38
GABRA1 P14867 1/20 0.38
GABRB2 P47870 1/20 0.38
MYC P01106 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1626644 0.81 TAS2R14 (0.50) ALOX15ALDH1A1KDM4EHPGDMAPT
SCHEMBL21258136 0.80 CA2 (0.39) ALOX15CA2ALDH1A1KDM4EMAPT
SCHEMBL31028133 0.79 ALDH1A1 (0.56) ALOX15CA2ALDH1A1KDM4EHPGD
SCHEMBL39249 0.79 ALDH1A1 (0.56) ALOX15CA2ALDH1A1KDM4EHPGD
SCHEMBL2443197 0.79 ALDH1A1 (0.60) ALOX15CA2ALDH1A1KDM4EHPGD
SCHEMBL273494 0.78 ALOX15 (0.47) ALOX15CA2ALDH1A1KDM4EHPGD
SCHEMBL39311 0.78 CA2 (0.61) ALOX15CA2ALDH1A1KDM4EHPGD
SCHEMBL10397067 0.78 TSHR (0.49) ALOX15CA2ALDH1A1KDM4EHPGD
SCHEMBL31229322 0.78 ALOX15 (0.47) ALOX15CA2ALDH1A1KDM4EHPGD
SCHEMBL1355526 0.78 ALOX15 (0.47) ALOX15CA2ALDH1A1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114163369-A Preparation method of sulfur/oxygen ester group-containing aromatic hydrocarbon compound 武汉工程大学 2022-03-11 CN disclosed