Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2898321 | 0.76 | HTR2A (0.41) | KCNJ1HTR2AHTR1AHTR1DAR | |
| SCHEMBL299742 | 0.73 | HTR2A (0.34) | KCNJ1HTR2AHTR1AHTR1D | |
| SCHEMBL2894905 | 0.73 | MEN1 (0.35) | KCNJ1KDM4EALDH1A1HTR2AHTR1A | |
| SCHEMBL299763 | 0.72 | HTR2A (0.45) | KCNJ1ALDH1A1HTR2ASLC6A4AR | |
| SCHEMBL300052 | 0.71 | GPR119 (0.40) | KCNJ1ALDH1A1MEN1KMT2A | |
| SCHEMBL13028045 | 0.71 | HTR2A (0.35) | KCNJ1KDM4EALDH1A1HTR2AHTR1A | |
| SCHEMBL4606848 | 0.61 | BCHE (0.42) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL296779 | 0.60 | MTNR1A (0.40) | HTR2AHTR1AHTR1D | |
| Propionic Acid SCHEMBL11674035 | 0.60 | SMN1; SMN2 (0.45) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7289317 | 0.60 | MAOA (0.42) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129379-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2010-11-11 | — | — | WO | disclosed |