Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 6/20 | 0.33 |
| ▸ | CPB1 | P15086 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28498700 | 0.86 | SLC15A2 (0.47) | SLC15A2CPB2CPB1MMP2MMP9 | |
| SCHEMBL5893967 | 0.85 | CPB2 (0.32) | CPB2CPB1 | |
| SCHEMBL5893971 | 0.85 | CPB2 (0.32) | CPB2CPB1 | |
| Histidine SCHEMBL18419548 | 0.84 | GSR (0.54) | GSRTHRBCPB2CPB1MMP2 | |
| Histidine SCHEMBL4297918 | 0.84 | GSR (0.54) | GSRTHRBCPB2CPB1MMP2 | |
| Histidine SCHEMBL305855 | 0.84 | GSR (0.54) | GSRTHRBCPB2CPB1MMP2 | |
| Histidine SCHEMBL4294462 | 0.84 | GSR (0.54) | GSRTHRBCPB2CPB1MMP2 | |
| Histidine SCHEMBL16714200 | 0.84 | GSR (0.54) | GSRTHRBCPB2CPB1MMP2 | |
| D-Histidine SCHEMBL902054 | 0.84 | GSR (0.54) | GSRTHRBCPB2CPB1MMP2 | |
| Histidine SCHEMBL305856 | 0.84 | GSR (0.54) | GSRTHRBCPB2CPB1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111808165-B | Synthetic method of GHK copper peptide | 中国计量大学 | 2022-03-04 | — | — | CN | disclosed |