SCHEMBL28720205

SCHEMBL28720205

Cc1csc(C)c1OC(=O)NC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LCK P06239 4/20 0.33
ALDH1A1 P00352 2/20 0.33
GAA P10253 2/20 0.33
MAPT P10636 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GLA P06280 1/20 0.31
HPGD P15428 1/20 0.31
MAPK1 P28482 1/20 0.31
THRB P10828 1/20 0.31
NPC1 O15118 2/20 0.30
RAB9A P51151 2/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
FYN P06241 1/20 0.30
SRC P12931 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28597596 0.74 LCK (0.42) LCKALDH1A1MAPTGLANPC1
SCHEMBL28936769 0.73 RAB9A (0.37) ALDH1A1GAAMAPTKDM4EGLA
SCHEMBL114172 0.73 ADRA2A (0.34) GAAMAPTTHRBMEN1KMT2A
SCHEMBL28713813 0.72 ALDH1A1 (0.37) LCKALDH1A1GAAKDM4EMAPK1
SCHEMBL28711899 0.71 MAPT (0.32) ALDH1A1GAAMAPT
SCHEMBL28707004 0.71 ALDH1A1 (0.40) ALDH1A1GAAMAPTHPGD
SCHEMBL6931371 0.70 ACHE (0.38) ALDH1A1GAAKDM4EGLAHPGD
SCHEMBL28716132 0.70 DAO (0.38) ALDH1A1GAAMAPTKDM4EGLA
SCHEMBL28717530 0.70 ALDH1A1 (0.41) ALDH1A1GAAKDM4EGLAHPGD
SCHEMBL28706986 0.69 ANO1 (0.40) ALDH1A1GAAMAPTKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114222739-A Sulfonylurea derivatives and use thereof 诺瑟拉有限公司 2022-03-22 CN disclosed