Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.59 |
| ▸ | CA9 | Q16790 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | L1CAM | P32004 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL77381 | 0.84 | CA1 (0.77) | CA1CA9RAB9AL1CAMKDM4E | |
| SCHEMBL28721688 | 0.78 | RAB9A (0.68) | CA1CA9RAB9AL1CAMKDM4E | |
| SCHEMBL6636585 | 0.77 | CA1 (0.79) | CA1CA9RAB9AL1CAMKDM4E | |
| SCHEMBL28721172 | 0.77 | RAB9A (0.66) | CA1CA9RAB9AL1CAMKDM4E | |
| SCHEMBL23978398 | 0.76 | KDM4E (0.65) | CA1CA9RAB9AL1CAMKDM4E | |
| SCHEMBL4218154 | 0.76 | CA1 (0.65) | CA1CA9RAB9AL1CAMKDM4E | |
| SCHEMBL29851354 | 0.76 | CA1 (0.65) | CA1CA9RAB9AL1CAMKDM4E | |
| SCHEMBL1169719 | 0.76 | CA1 (0.65) | CA1CA9RAB9AL1CAMKDM4E | |
| SCHEMBL6638020 | 0.76 | NPC1 (0.74) | CA1CA9RAB9AL1CAMKDM4E | |
| SCHEMBL6448644 | 0.74 | CA1 (0.62) | CA1CA9RAB9AL1CAMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689051-B | Use of inhibitors of mitochondrial activity for the treatment of acute myeloid leukemia with poor prognosis | 蒙特利尔大学 | 2022-03-29 | — | — | CN | disclosed |