Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | CA1 | P00915 | 4/20 | 0.65 |
| ▸ | CA9 | Q16790 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | CA12 | O43570 | 1/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.65 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.65 |
| ▸ | CA4 | P22748 | 1/20 | 0.65 |
| ▸ | CA6 | P23280 | 1/20 | 0.65 |
| ▸ | CA7 | P43166 | 1/20 | 0.65 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.65 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.65 |
| ▸ | L1CAM | P32004 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL77381 | 0.89 | CA1 (0.77) | KDM4ECA1CA9ALDH1A1SMN1; SMN2 | |
| SCHEMBL11700974 | 0.89 | ALDH1A1 (0.71) | ALDH1A1HPGDMAPTCYP2C9GAA | |
| SCHEMBL6638020 | 0.84 | NPC1 (0.74) | KDM4ECA1CA9ALDH1A1SMN1; SMN2 | |
| SCHEMBL29404721 | 0.83 | KMT2A (0.66) | ALDH1A1HPGDMAPTCYP2C9GAA | |
| SCHEMBL11413347 | 0.83 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTCYP2C9GAA | |
| Phthalic Acid SCHEMBL1162068 | 0.83 | ALDH1A1 (0.95) | KDM4ECA1CA9ALDH1A1SMN1; SMN2 | |
| SCHEMBL6638968 | 0.82 | KDM4E (0.67) | KDM4ECA1CA9ALDH1A1SMN1; SMN2 | |
| SCHEMBL11813318 | 0.82 | ALDH1A1 (0.79) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL6636585 | 0.82 | CA1 (0.79) | KDM4ECA1CA9ALDH1A1SMN1; SMN2 | |
| SCHEMBL11405554 | 0.81 | LMNA (0.76) | KDM4ECA1CA9ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021225982-A1 | SOS1 ALLOSTERIC SITE TARGETING | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2021-11-11 | — | — | WO | disclosed |
| US-20210338694-A1 | SOS1 ALLOSTERIC SITE TARGETING | UNIVERSITY OF CINCINNATI | 2021-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210338694-A1 | SOS1 ALLOSTERIC SITE TARGETING | SOS1, SOS2, SOST | KDM4E 4376/4885CA1 4567/4885CA9 4373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.