⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29551752 | 0.81 | — | — | |
| SCHEMBL31506894 | 0.79 | ALDH1A1 (0.39) | — | |
| SCHEMBL11129947 | 0.78 | PSIP1 (0.44) | — | |
| SCHEMBL329418 | 0.77 | — | — | |
| SCHEMBL353922 | 0.75 | — | — | |
| SCHEMBL18456 | 0.75 | — | — | |
| SCHEMBL9063607 | 0.75 | CCR2 (0.39) | — | |
| SCHEMBL1259869 | 0.75 | — | — | |
| SCHEMBL791265 | 0.75 | — | — | |
| SCHEMBL19869231 | 0.75 | CCR2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487821-B1 | BENZODIAZEPINE-SUBSTITUTED PIPERIDINES FOR UTILIZATION IN THE TREATMENT OF CARDIOVASCULAR DISEASES | BOEHRINGER INGELHEIM PHARMA (DE) | 2007-03-21 | — | — | EP | claimed |
| EP-0041465-A1 | Process for the preparation of 1-carbamoyl-3-(3,5-dichlorophenyl)-hydantoin, and 1-chlorocarbonyl-3-(3,5-dichlorophenyl) hydantoin as intermediate in this process | RHONE-POULENC AGROCHIMIE (FR) | 1981-12-09 | — | — | EP | claimed |
| US-12371422-B2 | Fluorine-containing pyrimidine compound and manufacturing method for same | UNIMATEC CO., LTD. (JP) | 2025-07-29 | — | — | US | disclosed |
| US-20240150329-A1 | FLUORINE-CONTAINING PYRIMIDINE COMPOUND AND MANUFACTURING METHOD FOR SAME | UNIMATEC CO., LTD. (JP) | 2024-05-09 | — | — | US | disclosed |
| EP-4247810-A1 | N-[(1,3-BENZOXAZOL-2-YL)-HETEROCYCLE]AMIDE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2023-09-27 | — | — | EP | disclosed |
| EP-4052759-A1 | FLUORINE-CONTAINING PYRIMIDINE COMPOUND AND MANUFACTURING METHOD FOR SAME | Unimatec Co., Ltd. (JP) | 2022-09-07 | — | — | EP | disclosed |
| WO-2022106680-A1 | N-[(1,3-BENZOXAZOL-2-YL)-HETEROCYCLE]AMIDE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2022-05-27 | — | — | WO | disclosed |
| US-RE47493-E1 | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-07-09 | — | — | US | disclosed |
| WO-2016131098-A1 | SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME | THE UNIVERSITY OF QUEENSLAND (AU) | 2016-08-25 | — | — | WO | disclosed |
| EP-2114917-B1 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL (JP) | 2016-08-10 | — | — | EP | disclosed |
| US-9115093-B2 | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-08-25 | — | — | US | disclosed |
| EP-0915814-B1 | METHOD FOR GRAFTING A SUBSTITUTED DIFLUOROMETHYLE GROUP | RHONE POULENC CHIMIE (FR) | 2001-11-14 | — | — | EP | disclosed |
| EP-0733614-B1 | Reagent and process useful for attaching a substituted difluoromethyl group onto a compound with at least one electrophilic function | RHODIA CHIMIE SA (FR) | 2001-05-23 | — | — | EP | disclosed |
| EP-0915814-A1 | METHOD FOR GRAFTING A SUBSTITUTED DIFLUOROMETHYLE GROUP | RHONE-POULENC CHIMIE (FR) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998005609-A1 | METHOD FOR GRAFTING A SUBSTITUTED DIFLUOROMETHYLE GROUP | RHODIA CHIMIE (FR) | 1998-02-12 | — | — | WO | disclosed |
| EP-0733614-A1 | Reagent and process useful for attaching a substituted difluoromethyl group onto a compound with at least one electrophilic function | RHONE-POULENC CHIMIE (FR) | 1996-09-25 | — | — | EP | disclosed |
| EP-0041465-B1 | PROCESS FOR THE PREPARATION OF 1-CARBAMOYL-3-(3,5-DICHLOROPHENYL)-HYDANTOIN, AND 1-CHLOROCARBONYL-3-(3,5-DICHLOROPHENYL) HYDANTOIN AS INTERMEDIATE IN THIS PROCESS | RHONE-POULENC AGROCHIMIE (FR) | 1984-07-25 | — | — | EP | disclosed |
| EP-0013250-B1 | PROCESS FOR THE PREPARATION OF UNSATURATED MONO-ETHERS OF DIPHENOLS | RHONE-POULENC AGROCHIMIE (FR) | 1984-03-14 | — | — | EP | disclosed |
| EP-0041465-A1 | Process for the preparation of 1-carbamoyl-3-(3,5-dichlorophenyl)-hydantoin, and 1-chlorocarbonyl-3-(3,5-dichlorophenyl) hydantoin as intermediate in this process | RHONE-POULENC AGROCHIMIE (FR) | 1981-12-09 | — | — | EP | disclosed |
| US-4282212-A | Immune-stimulating 1-(N-acylcarbamoyl)-2-cyanoaziridines | BOEHRINGER MANNHEIM GMBH (DE) | 1981-08-04 | — | — | US | disclosed |