Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzoyl Peroxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.69 |
| ▸ | HPGD | P15428 | 6/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | CA12 | O43570 | 1/20 | 0.69 |
| ▸ | CA1 | P00915 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 1/20 | 0.69 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.69 |
| ▸ | CA4 | P22748 | 1/20 | 0.69 |
| ▸ | CA6 | P23280 | 1/20 | 0.69 |
| ▸ | CA7 | P43166 | 1/20 | 0.69 |
| ▸ | CA9 | Q16790 | 1/20 | 0.69 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.69 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | F2 | P00734 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoyl Peroxide SCHEMBL8940146 | 0.90 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Benzoyl Peroxide SCHEMBL30511565 | 0.88 | F2 (0.77) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29483467 | 0.84 | HPGD (0.82) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL6948351 | 0.84 | HPGD (0.82) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1509155 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29360246 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29606432 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1967 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL8433746 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29362663 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12558374-B2 | Botanical film-forming acne compositions | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2026-02-24 | — | — | US | disclosed |
| US-20240374633-A1 | Botanical Film-Forming Acne Compositions | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2024-11-14 | — | — | US | disclosed |
| US-20210346425-A1 | BOTANICAL FILM-FORMING ACNE COMPOSITIONS | UNIV COLUMBIA (US) | 2021-11-11 | — | — | US | disclosed |
| CN-110585236-A | Acne composition formed by plant membrane | 纽约哥伦比亚大学的受托人 | 2019-12-20 | — | — | CN | disclosed |
| CN-109745261-A | A kind of scalp nursing solution and preparation method thereof | 中国人民解放军陆军特色医学中心 | 2019-05-14 | — | — | CN | disclosed |
| US-20190000761-A1 | METHODS OF TREATING ACNE USING NANOEMULSION COMPOSITIONS | NANOBIO CORPORATION (US) | 2019-01-03 | — | — | US | disclosed |
| EP-3328359-A2 | METHODS OF TREATING ACNE USING NANOEMULSION COMPOSITIONS | NanoBio Corporation (US) | 2018-06-06 | — | — | EP | disclosed |
| CN-105106108-B | Supermolecule control slow-release salicylic acid formula and its technology of preparing | 薇碧生物科技（上海）有限公司 | 2018-06-01 | — | — | CN | disclosed |
| CN-105147596-B | Water-soluble supermolecule salicylic acid gel technology | 薇碧生物科技（上海）有限公司 | 2018-06-01 | — | — | CN | disclosed |
| WO-2017023751-A2 | METHODS OF TREATING ACNE USING NANOEMULSION COMPOSITIONS | NANOBIO CORPORATION (US) | 2017-02-09 | — | — | WO | disclosed |
| US-20100226983-A1 | Compositions for treatment and prevention of acne, methods of making the compositions, and methods of use thereof | NANOBIO CORPORATION | 2010-09-09 | — | — | US | disclosed |
| WO-2010087964-A2 | COMPOSITIONS FOR TREATMENT AND PREVENTION OF ACNE, METHODS OF MAKING THE COMPOSITIONS, AND METHODS OF USE THEREOF | NANOBIO CORPORATION (US) | 2010-08-05 | — | — | WO | disclosed |
| CN-1764437-B | Topical pharmaceutical and/or cosmetic dispense systems | EDKO TRADING REPRESENTATION | 2010-05-12 | — | — | CN | disclosed |
| US-20070048234-A1 | COMPOSITIONS AND METHODS FOR TREATING ACNE | REVANCE THERAPEUTICS, INC. (US) | 2007-03-01 | — | — | US | disclosed |
| CN-1630506-A | Composition for cleansing skin and treating acne | JOHNSON & JOHNSON CONSUMER (US) | 2005-06-22 | — | — | CN | disclosed |
| CN-1494897-A | Composition material for removing dead skin and curing comedo | ���Ǿ� | 2004-05-12 | — | — | CN | disclosed |
| EP-0896541-A4 | — | — | 1999-03-24 | — | — | EP | disclosed |
| EP-0896541-A1 | SILVER-BASED PHARMACEUTICAL COMPOSITIONS | CAPELLI, Christopher C. (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997002038-A1 | SILVER-BASED PHARMACEUTICAL COMPOSITIONS | CAPELLI CHRISTOPHER C (US) | 1997-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12558374-B2 | Botanical film-forming acne compositions | ACACB, HMGCR, GRHPR | ALDH1A1 1073/4885HPGD 595/4885KDM4E 1894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.