SCHEMBL28739751

SCHEMBL28739751

O=c1ccoc2ccc(OC(F)(F)F)cc12

nearest known ligand 0.59

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.59
MAOA P21397 13/20 0.58
MAOB P27338 13/20 0.58
SIGMAR1 Q99720 6/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27767737 0.76 MAOB (0.68) ACHEMAOAMAOBSIGMAR1
SCHEMBL20274091 0.76 PIM1 (0.50) MAOA
SCHEMBL10519899 0.75 MAOB (0.69) ACHEMAOAMAOBSIGMAR1
SCHEMBL30742413 0.75 MAOA (0.62) ACHEMAOAMAOBSIGMAR1
SCHEMBL28465411 0.75 MAOA (0.62) ACHEMAOAMAOBSIGMAR1
SCHEMBL19400647 0.73 ACHE (0.54) ACHEMAOAMAOBSIGMAR1
SCHEMBL17321065 0.72 ALDH1A1 (0.42) MAOB
SCHEMBL2976539 0.72 SIGMAR1 (0.73) ACHEMAOAMAOBSIGMAR1
SCHEMBL5446831 0.72 PIM1 (0.48) MAOAMAOB
SCHEMBL1094182 0.72 MAOA (0.59) ACHEMAOAMAOBSIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114560837-B Chromone compound and preparation method and application thereof 五邑大学 2023-11-24 CN disclosed
CN-114560837-A Chromone compound and preparation method and application thereof 五邑大学 2022-05-31 CN disclosed