Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.53 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.53 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.53 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.53 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.53 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.53 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.52 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.52 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 6/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL2874480 | 1.00 | CASR (0.53) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Sulfuric Acid SCHEMBL2874479 | 1.00 | CASR (0.53) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL1491266 | 0.94 | CASR (0.58) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL1331214 | 0.94 | CASR (0.58) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL1331216 | 0.94 | CASR (0.58) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL1491268 | 0.94 | CASR (0.58) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL2873634 | 0.93 | CASR (0.59) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL2873629 | 0.93 | CASR (0.59) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL1505053 | 0.93 | CASR (0.59) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Bromide SCHEMBL1504864 | 0.93 | CASR (0.57) | CASRADRA2CSLC6A2HTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522869-B2 | Process for preparing Cinacalcet hydrochloride | ZACH SYSTEM S.P.A. (IT) | 2016-12-20 | — | — | US | disclosed |
| US-20140296574-A1 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2014-10-02 | — | — | US | disclosed |
| EP-2398763-A2 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | ZaCh System S.p.A. (IT) | 2011-12-28 | — | — | EP | disclosed |
| US-20110306794-A1 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | ZACH SYSTEM S.P.A. (IT) | 2011-12-15 | — | — | US | disclosed |
| WO-2010094674-A2 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | ZACH SYSTEM S.P.A. (IT) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296574-A1 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | SLC5A1, CA9, REN | ADRA2C 657/4885SLC6A2 323/4885OPRM1 1916/4885 |
| US-20110306794-A1 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | SLC5A1, CA9, REN | ADRA2C 657/4885SLC6A2 323/4885OPRM1 1916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.