Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | SYK | P43405 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27965372 | 0.86 | JAK2 (0.52) | ABCG2JAK2SYKTP53NPC1 | |
| SCHEMBL28753785 | 0.83 | SYK (0.61) | ABCG2JAK2SYKPRKAA2ALDH1A1 | |
| SCHEMBL20357748 | 0.82 | JAK2 (0.56) | ABCG2JAK2SYKPRKAA2ALDH1A1 | |
| SCHEMBL2422608 | 0.75 | ABCG2 (0.72) | ABCG2TP53NPC1RAB9AITK | |
| SCHEMBL23906211 | 0.73 | GSK3B (0.47) | JAK2NPC1RAB9AJAK3ALDH1A1 | |
| SCHEMBL30086842 | 0.73 | GSK3B (0.47) | JAK2NPC1RAB9AJAK3ALDH1A1 | |
| SCHEMBL24023433 | 0.72 | CHKA (0.66) | TP53NPC1RAB9APOLBALDH1A1 | |
| SCHEMBL3254958 | 0.72 | ACVR1 (0.55) | JAK2SYKJAK3CDK1KDR | |
| SCHEMBL8346049 | 0.72 | ABCG2 (0.67) | ABCG2TP53NPC1RAB9AITK | |
| SCHEMBL20529569 | 0.71 | PLK4 (0.72) | ABCG2JAK2JAK3KDRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | claimed |
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | disclosed |