Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.56 |
| ▸ | SYK | P43405 | 4/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27965372 | 0.86 | JAK2 (0.52) | JAK2SYKABCG2PLK4CYP2D6 | |
| SCHEMBL28753755 | 0.82 | ABCG2 (0.55) | JAK2SYKABCG2PRKAA2ACHE | |
| SCHEMBL28753785 | 0.75 | SYK (0.61) | JAK2SYKABCG2PRKAA2KDR | |
| SCHEMBL18123312 | 0.73 | ALDH1A1 (0.63) | CYP2D6CYP3A4CYP2C19TSHRCHRM2 | |
| SCHEMBL20529569 | 0.72 | PLK4 (0.72) | JAK2ABCG2PLK4KDRMAPK1 | |
| SCHEMBL14717210 | 0.72 | SYK (1.00) | JAK2SYK | |
| SCHEMBL2422608 | 0.71 | ABCG2 (0.72) | ABCG2CHEK1CDK1CYP2D6CYP3A4 | |
| SCHEMBL28941887 | 0.70 | NPC1 (0.59) | SYKABCG2PLK4KDRCYP2D6 | |
| SCHEMBL28227359 | 0.68 | ROCK2 (0.61) | JAK2SYKABCG2PLK4TSHR | |
| SCHEMBL8346049 | 0.68 | ABCG2 (0.67) | ABCG2CHEK1CDK1KDRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748166-B1 | PYRIMIDO-PYRIDAZINONE COMPOUNDS AND USE THEREOF | ASANA BIOSCIENCES LLC (US) | 2018-07-11 | — | — | EP | claimed |