Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.61 |
| ▸ | JAK2 | O60674 | 3/20 | 0.61 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28753755 | 0.83 | ABCG2 (0.55) | SYKJAK2PRKAA2ABCG2ALDH1A1 | |
| SCHEMBL27965372 | 0.79 | JAK2 (0.52) | SYKJAK2ABCG2ALDH1A1LMNA | |
| SCHEMBL14717035 | 0.76 | SYK (1.00) | SYKJAK2 | |
| SCHEMBL20357748 | 0.75 | JAK2 (0.56) | SYKJAK2PRKAA2ABCG2ALDH1A1 | |
| SCHEMBL28227359 | 0.70 | ROCK2 (0.61) | SYKJAK2ABCG2ALDH1A1 | |
| SCHEMBL2422608 | 0.69 | ABCG2 (0.72) | ABCG2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL15652315 | 0.68 | LMNA (0.55) | SYKJAK2ALDH1A1KMT2ALMNA | |
| SCHEMBL15976950 | 0.67 | CYP1A2 (0.48) | ALDH1A1KMT2ALMNA | |
| SCHEMBL15568151 | 0.67 | FAAH (0.62) | FAAH | |
| SCHEMBL23906211 | 0.67 | GSK3B (0.47) | JAK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | claimed |
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | disclosed |