Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.48 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.47 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.47 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL28752216 | 0.88 | NOTUM (0.50) | NOTUMMAPTPOLBL3MBTL1DRD2 | |
| SCHEMBL3050068 | 0.88 | NOTUM (0.50) | NOTUMDRD2DRD4HTR1AHTR2A | |
| Fumaric Acid SCHEMBL28752217 | 0.85 | BPTF (0.46) | NOTUMRAB9A | |
| Fumaric Acid SCHEMBL27601356 | 0.81 | HTR3A (0.44) | NOTUMALDH1A1KDM4E | |
| Fumaric Acid SCHEMBL27491916 | 0.79 | GPR119 (0.45) | — | |
| SCHEMBL27483062 | 0.77 | KMT2A (0.52) | ALDH1A1MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL3055453 | 0.76 | MBTD1 (0.51) | NOTUMMAPTMEN1POLBKMT2A | |
| Fumaric Acid SCHEMBL27601359 | 0.76 | CHRNA7 (0.46) | HTR1AHTR2AHRH1DRD3 | |
| Fumaric Acid SCHEMBL27491915 | 0.75 | GPR119 (0.43) | KDM4E | |
| SCHEMBL5832560 | 0.74 | MEN1 (0.56) | ALDH1A1GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100398103-C | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance | NEUROSEARCH AS (DK) | 2008-07-02 | — | — | CN | disclosed |
| CN-1635877-A | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance | NEUROSEARCH AS (DK) | 2005-07-06 | — | — | CN | disclosed |