Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.40 |
| ▸ | TUBB | P07437 | 2/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5348378 | 0.82 | AKR1B1 (0.46) | PTGS2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL5354957 | 0.79 | PTGS2 (0.58) | PTGS1PTGS2ALDH1A1HPGDMEN1 | |
| SCHEMBL1406276 | 0.78 | IDO1 (0.52) | ALDH1A1HPGDMEN1KMT2AIDO1 | |
| SCHEMBL1399334 | 0.77 | KIF11 (0.43) | PTGS1PTGS2ALDH1A1HPGDMEN1 | |
| SCHEMBL1399484 | 0.77 | PTGS1 (0.45) | PTGS1PTGS2ALDH1A1HPGDMEN1 | |
| SCHEMBL5110119 | 0.77 | PTGS2 (0.79) | PTGS1PTGS2 | |
| SCHEMBL27605864 | 0.76 | IDO1 (0.50) | PTGS1PTGS2ALDH1A1HPGDMEN1 | |
| SCHEMBL5353455 | 0.76 | ALDH1A1 (0.47) | PTGS1PTGS2ALDH1A1HPGDMEN1 | |
| SCHEMBL27605921 | 0.73 | IDO1 (0.47) | ALDH1A1MEN1KMT2AIDO1KDM4E | |
| SCHEMBL1406150 | 0.73 | IDO1 (0.59) | PTGS1PTGS2IDO1TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100404505-C | Novel substituted indoles | ASTRAZENECA AB (SE) | 2008-07-23 | — | — | CN | disclosed |
| CN-1671659-A | Novel substituted indoles | ASTRAZENECA AB (SE) | 2005-09-21 | — | — | CN | disclosed |