Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.56 |
| ▸ | TUBB | P07437 | 3/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.56 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.56 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.56 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.56 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.56 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.56 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.56 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.56 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.56 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5354957 | 0.85 | PTGS2 (0.58) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL27605864 | 0.85 | IDO1 (0.50) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5362568 | 0.82 | SMN1; SMN2 (0.48) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5349617 | 0.82 | PTGS2 (0.62) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3006431 | 0.82 | IDO1 (0.53) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1406276 | 0.81 | IDO1 (0.52) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL16240117 | 0.81 | MAPT (0.53) | MAPT | |
| SCHEMBL1406147 | 0.81 | ENPP2 (0.62) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL16240084 | 0.78 | TUBB4A (0.67) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6529434 | 0.77 | IDO1 (0.47) | IDO1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513812-B1 | SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2011-03-09 | — | — | EP | disclosed |
| US-20100197756-A1 | Indole-3-Sulphur Derivatives | ASTRAZENECA AB (SE) | 2010-08-05 | — | — | US | disclosed |
| US-7723373-B2 | Indole-3-sulphur derivatives | ASTRAZENECA AB (SE) | 2010-05-25 | — | — | US | disclosed |
| EP-1551802-B1 | INDOLE-3-SULPHUR DERIVATIVES | ASTRAZENECA AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| CN-100404505-C | Novel substituted indoles | ASTRAZENECA AB (SE) | 2008-07-23 | — | — | CN | disclosed |
| US-7166607-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2007-01-23 | — | — | US | disclosed |
| US-20060111426-A1 | Indole-3-sulphur derivaties | ASTRAZENECA AB (SE) | 2006-05-25 | — | — | US | disclosed |
| CN-1671659-A | Novel substituted indoles | ASTRAZENECA AB (SE) | 2005-09-21 | — | — | CN | disclosed |
| US-20050165055-A1 | Novel substituted indoles | ASTRAZENECA AB (SE) | 2005-07-28 | — | — | US | disclosed |
| EP-1513812-A1 | SUBSTITUTED INDOLES | AstraZeneca AB (SE) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003101961-A1 | NOVEL SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165055-A1 | Novel substituted indoles | IDO1, IDO2, TPH1 | IDO1 1/4885TUBB4A 1248/4885TUBB 910/4885 |
| US-20100197756-A1 | Indole-3-Sulphur Derivatives | IDO1, IDO2, INMT | IDO1 1/4885TUBB4A 1833/4885TUBB 1182/4885 |
| US-20060111426-A1 | Indole-3-sulphur derivaties | IDO1, IDO2, INMT | IDO1 1/4885TUBB4A 2511/4885TUBB 2031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.