Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12732677 | 0.87 | ALDH1A1 (0.47) | TTRHSD17B10ALDH1A1HPGDALOX15 | |
| SCHEMBL12733465 | 0.86 | ALDH1A1 (0.50) | HSD17B10ALDH1A1HPGDALOX15TDP1 | |
| SCHEMBL10708734 | 0.86 | ALDH1A1 (0.50) | TTRHSD17B10ALDH1A1HPGDALOX15 | |
| SCHEMBL6015487 | 0.85 | ALDH1A1 (0.61) | TTRHSD17B10ALDH1A1HPGDALOX15 | |
| SCHEMBL12732630 | 0.85 | ALDH1A1 (0.48) | TTRHSD17B10ALDH1A1HPGDALOX15 | |
| SCHEMBL12732639 | 0.85 | RAB9A (0.49) | HSD17B10ALDH1A1HPGDALOX15TDP1 | |
| SCHEMBL12732756 | 0.84 | ALDH1A1 (0.52) | TTRHSD17B10ALDH1A1HPGDALOX15 | |
| SCHEMBL12732658 | 0.84 | ALDH1A1 (0.52) | TTRHSD17B10ALDH1A1HPGDALOX15 | |
| SCHEMBL12733501 | 0.83 | ALDH1A1 (0.47) | TTRHSD17B10ALDH1A1HPGDALOX15 | |
| SCHEMBL12732734 | 0.83 | L3MBTL1 (0.48) | HSD17B10ALDH1A1HPGDALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243401-A1 | METHODS OF SCREENING COMPOUNDS THAT ARE CYTOTOXIC TO TUMOR CELLS AND METHODS OF TREATING TUMOR CELLS USING SUCH COMPOUND | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-08-28 | — | — | US | disclosed |
| EP-2655706-A2 | METHODS OF SCREENING COMPOUNDS THAT ARE CYTOTOXIC TO TUMOR CELLS AND METHODS OF TREATING TUMOR CELLS USING SUCH COMPOUND | Ronnett, Gabrielle (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012071562-A2 | METHODS OF SCREENING COMPOUNDS THAT ARE CYTOTOXIC TO TUMOR CELLS AND METHODS OF TREATING TUMOR CELLS USING SUCH COMPOUND | RONNETT GABRIELLE (US) | 2012-05-31 | — | — | WO | disclosed |
| US-7932283-B2 | Fungicide N-cyclopropyl-sulfonylamide derivatives | BAYER CROPSCIENCE AG (DE) | 2011-04-26 | — | — | US | disclosed |
| US-7687547-B2 | Diphenyl ether antimicrobial compounds | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2010-03-30 | — | — | US | disclosed |
| US-20090137611-A1 | Fungicide N-Cyclopropyl-Sulfonylamide Derivatives | BAYER CROPSCIENCE AG (DE) | 2009-05-28 | — | — | US | disclosed |
| US-20060041025-A1 | 5-Alkyl (4-26 carbon atoms)-2-phenoxyphenols; enoyl reductase enzyme inhibitor; drug resistance; side-effect reduction; nicrobiocides; carriers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137611-A1 | Fungicide N-Cyclopropyl-Sulfonylamide Derivatives | CYP51A1, ERG28, CBR3 | TTR 2985/4885HSD17B10 1544/4885ALDH1A1 2140/4885 |
| US-20060041025-A1 | 5-Alkyl (4-26 carbon atoms)-2-phenoxyphenols; enoyl reductase enzyme inhibitor; drug resistance; side-effect reduction; nicrobiocides; carriers | CBR1, CBR3, FAR1 | TTR 3309/4885HSD17B10 73/4885ALDH1A1 855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.