Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 3/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28758462 | 0.79 | CA2 (0.53) | CA2LMNAF2PRSS1PRSS2 | |
| SCHEMBL23319836 | 0.76 | RAPGEF3 (0.40) | CYP19A1PKMALDH1A1 | |
| SCHEMBL29909995 | 0.76 | RAPGEF3 (0.40) | CYP19A1PKMALDH1A1 | |
| SCHEMBL29973441 | 0.72 | LMNA (0.69) | POLBPRMT1HTR6CA2LMNA | |
| SCHEMBL2018411 | 0.72 | LMNA (0.69) | POLBPRMT1HTR6CA2LMNA | |
| SCHEMBL21962677 | 0.72 | CA12 (0.55) | CA2LMNACYP19A1CA12CA1 | |
| SCHEMBL5673665 | 0.72 | POLB (0.69) | POLBPRMT1HTR6CA2LMNA | |
| SCHEMBL22266027 | 0.72 | KEAP1 (0.41) | POLBHTR6LMNAALDH1A1HSD17B10 | |
| SCHEMBL21962605 | 0.71 | NR1I2 (0.39) | POLBLMNAPKMALDH1A1SMN1; SMN2 | |
| SCHEMBL687474 | 0.70 | LMNA (0.61) | POLBPRMT1HTR6CA2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114591293-A | Fused ring compound as Nav1.8 inhibitor and application thereof | 成都康弘药业集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |