SCHEMBL28759698

SCHEMBL28759698

CC(C)(C)c1cc(Cl)c(Br)c(Cl)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRB2 P47870 2/20 0.40
GABRA1 P14867 1/20 0.40
POLB P06746 1/20 0.37
CYP2C19 P33261 3/20 0.34
HIF1A Q16665 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
ACLY P53396 1/20 0.33
HTR1D P28221 1/20 0.32
TSHR P16473 3/20 0.32
ALDH1A1 P00352 2/20 0.31
HPGD P15428 2/20 0.31
ALOX15 P16050 2/20 0.31
HSD17B10 Q99714 2/20 0.31
TDP1 Q9NUW8 2/20 0.31
CYP3A4 P08684 1/20 0.31
ALOX12 P18054 1/20 0.31
CASP1 P29466 1/20 0.31
RECQL P46063 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29306738 0.86 RXRB (0.40) GABRB2GABRA1POLBCYP2C19HIF1A
SCHEMBL22915643 0.78 CYP2C19 (0.38) GABRB2GABRA1POLBCYP2C19HIF1A
SCHEMBL29419466 0.78 CYP2C19 (0.38) GABRB2GABRA1POLBCYP2C19HIF1A
SCHEMBL13249069 0.78 ALDH1A1 (0.45) GABRB2GABRA1POLBCYP2C19ACLY
SCHEMBL13166875 0.76 GABRB2 (0.42) GABRB2GABRA1POLBCYP2C19ACLY
SCHEMBL1755242 0.76 POLB (0.44) GABRB2GABRA1POLBCYP2C19HIF1A
SCHEMBL6456633 0.75 CA1 (0.46) GABRB2GABRA1POLBCYP2C19HIF1A
SCHEMBL814586 0.75 TSHR (0.54) GABRB2GABRA1CYP2C19HIF1ACYP1A2
SCHEMBL6321690 0.74 GABRA1 (0.40) GABRB2GABRA1POLBCYP2C19ACLY
SCHEMBL22819558 0.74 CYP2C19 (0.41) GABRB2GABRA1POLBCYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114621270-B Condensed ring aromatic compound and application thereof in electroluminescent device 清华大学 2024-04-12 CN disclosed
CN-114621269-B Condensed ring aromatic compound and application thereof in electroluminescent device 清华大学 2024-04-09 CN disclosed
CN-114621269-A Fused aromatic compound and application thereof in electroluminescent device 清华大学 2022-06-14 CN disclosed
CN-114621270-A Fused aromatic compound and application thereof in electroluminescent device 清华大学 2022-06-14 CN disclosed