Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298251 | 0.90 | GPR119 (0.45) | GPR119TBK1 | |
| SCHEMBL759241 | 0.89 | GPR119 (0.36) | GPR119CYP2C9 | |
| SCHEMBL298072 | 0.84 | GPR119 (0.46) | GPR119TBK1 | |
| SCHEMBL13034608 | 0.83 | GPR119 (0.38) | GPR119CYP2C9 | |
| SCHEMBL297959 | 0.82 | GPR119 (0.48) | GPR119CYP2C9 | |
| SCHEMBL3512362 | 0.80 | GPR119 (0.36) | GPR119CYP2C9 | |
| SCHEMBL290047 | 0.80 | GPR119 (0.36) | GPR119CYP2C9 | |
| SCHEMBL757014 | 0.80 | GPR119 (0.36) | GPR119CYP2C9 | |
| SCHEMBL300080 | 0.80 | GPR119 (0.36) | GPR119CYP2C9 | |
| SCHEMBL756660 | 0.79 | GPR119 (0.35) | GPR119CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427450-A1 | GPR 119 MODULATORS | Pfizer Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| EP-2427448-A1 | Gpr 119 modulators | Pfizer Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128425-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010128414-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2010-11-11 | — | — | WO | disclosed |