SCHEMBL2876751

SCHEMBL2876751

N[C@@H](CNC(=O)O)Cc1ccccc1

nearest known ligand 0.73

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 5/20 0.73
EPHX1 P07099 1/20 0.57
ALPI P09923 1/20 0.53
PKM P14618 1/20 0.53
PTGS1 P23219 1/20 0.53
XIAP P98170 1/20 0.53
SLC7A5 Q01650 1/20 0.53
GGT1 P19440 2/20 0.52
ANPEP P15144 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL218878 1.00 MMP2 (0.73) MMP2EPHX1ALPIPKMPTGS1
SCHEMBL218877 1.00 MMP2 (0.73) MMP2EPHX1ALPIPKMPTGS1
Hydrochloric Acid SCHEMBL23051768 0.98 MMP2 (0.71) MMP2EPHX1ALPIPKMPTGS1
Hydrochloric Acid SCHEMBL23051769 0.98 MMP2 (0.71) MMP2EPHX1ALPIPKMPTGS1
SCHEMBL4343987 0.90 MMP2 (0.60) MMP2GGT1
SCHEMBL4343992 0.90 MMP2 (0.60) MMP2GGT1
SCHEMBL20717803 0.87 MMP2 (0.71) MMP2EPHX1ALPIPKMPTGS1
SCHEMBL20717933 0.87 MMP2 (0.71) MMP2EPHX1ALPIPKMPTGS1
SCHEMBL20630479 0.86 MMP2 (0.69) MMP2EPHX1ALPIPKMPTGS1
Hydrochloric Acid SCHEMBL20704629 0.86 MMP2 (0.69) MMP2EPHX1ALPIPKMPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4626417-A1 METHODS AND COMPOSITIONS FOR IMPROVING DRIVING PERFORMANCE AXSOME THERAPEUTICS (US) 2025-10-08 EP claimed
US-12318362-B2 Methods of providing solriamfetol therapy to subjects with impaired renal function AXSOME MALTA LTD. (MT) 2025-06-03 US claimed
US-20250152548-A1 METHODS OF PROVIDING SOLRIAMFETOL THERAPY TO SUBJECTS WITH IMPAIRED RENAL FUNCTION WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-05-15 US claimed
US-20250108030-A1 METHODS OF PROVIDING SOLRIAMFETOL THERAPY TO SUBJECTS WITH IMPAIRED RENAL FUNCTION WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-04-03 US claimed
US-12194016-B2 Methods of providing solriamfetol therapy to subjects with impaired renal function AXSOME MALTA LTD. (MT) 2025-01-14 US claimed
EP-4232428-B1 NOVEL PROCESS FOR PREPARING SOLRIAMFETOL HYDROCHLORIDE PROCOS SPA (IT) 2024-11-13 EP claimed
US-20240252462-A1 METHODS OF PROVIDING SOLRIAMFETOL THERAPY TO SUBJECTS WITH IMPAIRED RENAL FUNCTION WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-08-01 US claimed
EP-4395763-A1 METHODS AND COMPOSITIONS FOR AMELIORATING BIOMARKERS ASSOCIATED WITH CARDIOVASCULAR RISK USING (R)-2-AMINO-3-PHENYLPROPYL CARBAMATE AXSOME THERAPEUTICS (US) 2024-07-10 EP claimed
WO-2024118904-A1 METHODS AND COMPOSITIONS FOR IMPROVING DRIVING PERFORMANCE AXSOME THERAPEUTICS (US) 2024-06-06 WO claimed
US-11986455-B2 Methods of providing solriamfetol therapy to subjects with impaired renal function AXSOME MALTA LTD. (MT) 2024-05-21 US claimed
CN-109906078-B Formulations of (R) -2-amino-3-phenylpropylcarbamate 爵士制药国际III有限公司 2022-09-13 CN claimed
US-20220000831-A1 METHODS OF PROVIDING SOLRIAMFETOL THERAPY TO SUBJECTS WITH IMPAIRED RENAL FUNCTION WILMINGTON TRUST, NATIONAL ASSOCIATION 2022-01-06 US claimed
US-11160779-B2 Methods of providing solriamfetol therapy to subjects with impaired renal function JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) 2021-11-02 US claimed
US-20210290589-A1 METHODS OF PROVIDING SOLRIAMFETOL THERAPY TO SUBJECTS WITH IMPAIRED RENAL FUNCTION WILMINGTON TRUST, NATIONAL ASSOCIATION 2021-09-23 US claimed
US-20210205257-A1 METHODS AND COMPOSITIONS FOR TREATING EXCESSIVE SLEEPINESS WILMINGTON TRUST, NATIONAL ASSOCIATION 2021-07-08 US claimed
US-10959976-B2 Methods and compositions for treating excessive sleepiness JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) 2021-03-30 US claimed
US-10940133-B1 Methods of providing solriamfetol therapy to subjects with impaired renal function JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) 2021-03-09 US claimed
US-10912754-B2 Methods and compositions for treating excessive sleepiness JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) 2021-02-09 US claimed
US-20200281886-A1 METHODS AND COMPOSITIONS FOR TREATING EXCESSIVE SLEEPINESS WILMINGTON TRUST, NATIONAL ASSOCIATION 2020-09-10 US claimed
EP-2496228-B1 METHODS FOR TREATING ATTENTION-DEFICIT/HYPERACTIVITY DISORDER SK BIOPHARMACEUTICALS CO LTD (KR) 2014-01-15 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250152548-A1 METHODS OF PROVIDING SOLRIAMFETOL THERAPY TO SUBJECTS WITH IMPAIRED RENAL FUNCTION GLS, GRHPR, AGXT MMP2 1747/4885EPHX1 1773/4885ALPI 1758/4885
US-20200281886-A1 METHODS AND COMPOSITIONS FOR TREATING EXCESSIVE SLEEPINESS CHAT, PNMT, HCRTR1 MMP2 3312/4885EPHX1 1253/4885ALPI 2786/4885
US-10959976-B2 Methods and compositions for treating excessive sleepiness CHAT, PNMT, HCRTR1 MMP2 3312/4885EPHX1 1253/4885ALPI 2786/4885
US-20220000831-A1 METHODS OF PROVIDING SOLRIAMFETOL THERAPY TO SUBJECTS WITH IMPAIRED RENAL FUNCTION GLS, GRHPR, AGXT MMP2 1747/4885EPHX1 1773/4885ALPI 1758/4885
US-12194016-B2 Methods of providing solriamfetol therapy to subjects with impaired renal function GLS, GRHPR, AGXT MMP2 1747/4885EPHX1 1773/4885ALPI 1758/4885
US-11160779-B2 Methods of providing solriamfetol therapy to subjects with impaired renal function GLS, GRHPR, AGXT MMP2 1747/4885EPHX1 1773/4885ALPI 1758/4885
US-20210205257-A1 METHODS AND COMPOSITIONS FOR TREATING EXCESSIVE SLEEPINESS CHAT, PNMT, HCRTR1 MMP2 3312/4885EPHX1 1253/4885ALPI 2786/4885
US-11986455-B2 Methods of providing solriamfetol therapy to subjects with impaired renal function GLS, GRHPR, AGXT MMP2 1747/4885EPHX1 1773/4885ALPI 1758/4885
US-12318362-B2 Methods of providing solriamfetol therapy to subjects with impaired renal function GLS, GRHPR, AGXT MMP2 1747/4885EPHX1 1773/4885ALPI 1758/4885
US-20240252462-A1 METHODS OF PROVIDING SOLRIAMFETOL THERAPY TO SUBJECTS WITH IMPAIRED RENAL FUNCTION GLS, GRHPR, AGXT MMP2 1747/4885EPHX1 1773/4885ALPI 1758/4885
US-10940133-B1 Methods of providing solriamfetol therapy to subjects with impaired renal function GLS, GRHPR, AGXT MMP2 1747/4885EPHX1 1773/4885ALPI 1758/4885
US-20210290589-A1 METHODS OF PROVIDING SOLRIAMFETOL THERAPY TO SUBJECTS WITH IMPAIRED RENAL FUNCTION GLS, GRHPR, AGXT MMP2 1747/4885EPHX1 1773/4885ALPI 1758/4885
US-10912754-B2 Methods and compositions for treating excessive sleepiness CHAT, PNMT, HCRTR1 MMP2 3312/4885EPHX1 1253/4885ALPI 2786/4885
US-20250108030-A1 METHODS OF PROVIDING SOLRIAMFETOL THERAPY TO SUBJECTS WITH IMPAIRED RENAL FUNCTION GLS, GRHPR, AGXT MMP2 1747/4885EPHX1 1773/4885ALPI 1758/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.