Sugi Predict

Sugi Predict / Compounds / SCHEMBL2877136

SCHEMBL2877136

SCHEMBL2877136

[O-][n+]1ccc(OCc2ccc(Cl)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 5/20 0.58
▸ APP P05067 1/20 0.58
▸ NR4A2 P43354 1/20 0.51
▸ MAOA P21397 1/20 0.50
▸ GPR84 Q9NQS5 2/20 0.46
▸ DHFR P00374 1/20 0.46
▸ BCHE P06276 1/20 0.44
▸ IDO1 P14902 1/20 0.44
▸ AGXT P21549 1/20 0.44
▸ LMNA P02545 2/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ CCR6 P51684 1/20 0.43
▸ UBE2N P61088 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10991891 0.82 MAOB (0.80) MAOBAPPNR4A2MAOADHFR
SCHEMBL10104014 0.81 MAOB (0.58) MAOBAPPNR4A2MAOANPC1
SCHEMBL557817 0.81 LMNA (0.57) MAOBAPPNR4A2MAOABCHE
SCHEMBL18154523 0.80 APP (0.61) MAOBAPPBCHEIDO1AGXT
SCHEMBL17810144 0.80 MAOB (0.62) MAOBNR4A2MAOADHFRIDO1
SCHEMBL3476988 0.77 MAOB (0.61) MAOBMAOAIDO1
SCHEMBL11121647 0.77 MAOB (0.67) MAOBAPPNR4A2MAOADHFR
SCHEMBL5441069 0.76 MAOB (0.66) MAOBAPPNR4A2MAOABCHE
SCHEMBL17810160 0.76 MMP1 (0.49) MAOBAPP
SCHEMBL11600066 0.75 MAOB (0.69) MAOBAPPNR4A2MAOADHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170204095-A1 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES APOLLO ADMINISTRATIVE AGENCY LLC, AS SUCCESSOR AGENT 2017-07-20 — — US disclosed
US-20170204095-A1 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES APOLLO ADMINISTRATIVE AGENCY LLC, AS SUCCESSOR AGENT 2017-07-20 — — US disclosed
US-9650378-B2 (1-azinone)-substituted pyridoindoles ALBANY MOLECULAR RESEARCH, INC. (US) 2017-05-16 — — US disclosed
US-9650378-B2 (1-azinone)-substituted pyridoindoles ALBANY MOLECULAR RESEARCH, INC. (US) 2017-05-16 — — US disclosed
US-20160159798-A1 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES HARMONY BIOSCIENCES, LLC 2016-06-09 — — US disclosed
US-20160159798-A1 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES HARMONY BIOSCIENCES, LLC 2016-06-09 — — US disclosed
US-9296743-B2 (1-azinone)-substituted pyridoindoles ALBANY MOLECULAR RESEARCH, INC. (US) 2016-03-29 — — US disclosed
EP-2476680-B1 (1-Azinone)-Substituted Pyridoindoles ALBANY MOLECULAR RES INC (US) 2014-08-27 — — EP disclosed
US-20140206696-A1 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES ALBANY MOLECULAR RESEARCH, INC. (US) 2014-07-24 — — US disclosed
US-8716308-B2 (1-azinone)-substituted pyridoindoles ALBANY MOLECULAR RESEARCH, INC. (US) 2014-05-06 — — US disclosed
WO-2012169571-A1 NOVEL N-(PYRIDIN-2-YL)ALKANAMIDE DERIVATIVE AND SHIP2 INHIBITOR CONTAINING SAME AS AN ACTIVE INGREDIENT 国立大学法人 富山大学 (JP) 2012-12-13 — — WO disclosed
EP-2476680-A1 (1-Azinone)-Substituted Pyridoindoles Albany Molecular Research, Inc. (US) 2012-07-18 — — EP disclosed
US-20100331339-A9 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES ALBANY MOLECULAR RESEARCH, INC. (US) 2010-12-30 — — US disclosed
EP-2240481-A1 (1-AZINONE) -SUBSTITUTED PYRIDOINDOLES AS MCH ANTAGONISTS Albany Molecular Research, Inc. (US) 2010-10-20 — — EP disclosed
US-20100216758-A1 Pyridone Compounds MSD K.K. (JP) 2010-08-26 — — US disclosed
US-20090275590-A1 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES ALBANY MOLECULAR RESEARCH, INC. (US) 2009-11-05 — — US disclosed
WO-2009120655-A1 INDOLE DERIVATIVES H. LUNDBECK A/S (DK) 2009-10-01 — — WO disclosed
WO-2009089482-A1 (1-AZINONE) -SUBSTITUTED PYRIDOINDOLES AS MCH ANTAGONISTS ALBANY MOLECULAR RESEARCH, INC. (US) 2009-07-16 — — WO disclosed
EP-1916239-A1 PYRIDONE COMPOUND BANYU PHARMACEUTICAL CO., LTD. (JP) 2008-04-30 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100331339-A9 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES NR3C2, NR0B1, NR3C1 MAOB 1038/4885APP 3159/4885NR4A2 17/4885
US-20100216758-A1 Pyridone Compounds NPY1R, MC5R, MC1R MAOB 70/4885APP 2814/4885NR4A2 414/4885
US-20170204095-A1 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES NR3C2, NR2E3, NR0B1 MAOB 1090/4885APP 2905/4885NR4A2 17/4885
US-20090275590-A1 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES NR3C2, NR0B1, NR3C1 MAOB 1038/4885APP 3159/4885NR4A2 17/4885
US-20140206696-A1 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES NR3C2, NR2E3, NR0B1 MAOB 1090/4885APP 2905/4885NR4A2 17/4885
US-20160159798-A1 (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES NR3C2, NR2E3, NR0B1 MAOB 1090/4885APP 2905/4885NR4A2 17/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.