SCHEMBL5441069

SCHEMBL5441069

Clc1ccc(COc2ccccc2)cc1

nearest known ligand 0.78

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.66
APP P05067 2/20 0.66
NR4A2 P43354 2/20 0.62
BCHE P06276 2/20 0.61
MAOA P21397 2/20 0.56
LMNA P02545 1/20 0.55
CYP1A2 P05177 1/20 0.55
PTGS1 P23219 1/20 0.55
SLC6A2 P23975 1/20 0.55
CYP2C19 P33261 1/20 0.55
PTGS2 P35354 1/20 0.55
SLC6A3 Q01959 1/20 0.55
HIF1A Q16665 1/20 0.55
HDAC6 Q9UBN7 1/20 0.55
FFAR1 O14842 1/20 0.55
AR P10275 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23987 0.92 NR4A2 (0.60) MAOBAPPNR4A2BCHEMAOA
SCHEMBL11857425 0.92 MAOB (0.62) MAOBAPPNR4A2BCHEMAOA
SCHEMBL197223 0.91 LMNA (0.67) MAOBAPPNR4A2BCHEMAOA
SCHEMBL27417060 0.91 AR (0.58) MAOBAPPNR4A2BCHEMAOA
SCHEMBL10991891 0.89 MAOB (0.80) MAOBAPPNR4A2BCHEMAOA
SCHEMBL850999 0.89 APP (0.78) MAOBAPPNR4A2BCHEMAOA
SCHEMBL11846870 0.88 BCHE (0.63) MAOBAPPNR4A2BCHEMAOA
SCHEMBL10609652 0.84 LMNA (0.75) MAOBAPPNR4A2BCHEMAOA
SCHEMBL28999626 0.84 NR4A2 (0.61) MAOBNR4A2MAOA
Benzylphenylether SCHEMBL61660 0.84 LMNA (0.74) MAOBAPPNR4A2BCHEMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1979978-B1 NONAQUEOUS ELECTROLYTE INCLUDING DIPHENYL ETHER AND LITHIUM SECONDARY BATTERY USING THEREOF PANAX ETEC CO LTD (KR) 2016-04-06 EP disclosed
US-20120283266-A1 LYSINE SPECIFIC DEMETHYLASE-1 INHIBITORS AND THEIR USE ORYZON GENOMICS S.A. (ES) 2012-11-08 US disclosed
WO-2011035941-A1 LYSINE SPECIFIC DEMETHYLASE-1 INHIBITORS AND THEIR USE ORYZON GENOMICS S.A. (ES) 2011-03-31 WO disclosed
US-7501510-B2 Thiourea compositions and uses thereof THE UNIVERSITY OF HONG KONG (CN) 2009-03-10 US disclosed
CN-1304380-C Benzo[a]henazin-11-carboxamide derivatives and their use as joint inhibitors of topomerase I and II XENOVA LTD (GB) 2007-03-14 CN disclosed
US-20070043026-A1 Dopamine receptor modulators as antipsychotic agents GLAXO GROUP LIMITED (GB) 2007-02-22 US disclosed
EP-1503989-A1 DOPAMINE RECEPTOR MODULATORS AS ANTIPSYCHOTIC AGENTS GLAXO GROUP LIMITED (GB) 2005-02-09 EP disclosed
WO-2003095428-A1 DOPAMINE RECEPTOR MODULATORS AS ANTIPSYCHOTIC AGENTS GLAXO GROUP LIMITED (GB) 2003-11-20 WO disclosed
CN-1433406-A Benzo [ a ] phenazine-11-amide derivatives and their use as combined topoisomerase I and II inhibitors XENOVA LTD (GB) 2003-07-30 CN disclosed
EP-1240148-A1 BENZO[A]PHENAZIN-11-CARBOXAMIDE DERIVATIVES AND THEIR USE AS JOINT INHIBITORS OF TOPOMERASE I AND II Xenova Limited (GB) 2002-09-18 EP disclosed
WO-2001046157-A1 BENZO[A]PHENAZIN-11-CARBOXAMIDE DERIVATIVES AND THEIR USE AS JOINT INHIBITORS OF TOPOMERASE I AND II XENOVA LIMITED (GB) 2001-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120283266-A1 LYSINE SPECIFIC DEMETHYLASE-1 INHIBITORS AND THEIR USE JMJD6, KDM3A, KDM1A MAOB 186/4885APP 4824/4885NR4A2 2756/4885
US-20070043026-A1 Dopamine receptor modulators as antipsychotic agents SIGMAR1, CHRM1, OPRM1 MAOB 291/4885APP 3231/4885NR4A2 535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.