Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 17/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.42 |
| ▸ | EIF2AK1 | Q9BQI3 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22418477 | 0.84 | TEK (0.52) | EIF2AK3EGFRSRCFLT3MET | |
| SCHEMBL20351734 | 0.80 | SRC (0.49) | EIF2AK3CYP3A4EIF2AK2EIF2AK1EGFR | |
| SCHEMBL23043903 | 0.79 | FLT3 (0.50) | EIF2AK3CYP3A4EIF2AK2EIF2AK1EGFR | |
| SCHEMBL23057572 | 0.78 | FLT3 (0.44) | EIF2AK3EGFRCDK1SRCFLT3 | |
| SCHEMBL29746667 | 0.78 | FLT3 (0.44) | EIF2AK3EGFRCDK1SRCFLT3 | |
| SCHEMBL30060901 | 0.75 | FLT3 (0.56) | EIF2AK3CDK1SRCFLT3MET | |
| SCHEMBL29746671 | 0.75 | MAPT (0.49) | EIF2AK3EGFRSRCRIPK1 | |
| SCHEMBL23043988 | 0.75 | MAPT (0.49) | EIF2AK3EGFRSRCRIPK1 | |
| SCHEMBL23043916 | 0.74 | FLT3 (0.55) | EIF2AK3EGFRCDK1SRCFLT3 | |
| SCHEMBL29684025 | 0.74 | FLT3 (0.55) | EIF2AK3EGFRCDK1SRCFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114710956-A | PERK-INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | 希伯塞尔股份有限公司 | 2022-07-05 | — | — | CN | claimed |
| CN-114710956-A | PERK-INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | 希伯塞尔股份有限公司 | 2022-07-05 | — | — | CN | disclosed |