Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | ATM | Q13315 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28770717 | 0.80 | KDM4E (0.35) | MEN1KMT2AMAPTTDP1KDM4E | |
| SCHEMBL25178380 | 0.78 | MAPT (0.48) | MEN1KMT2AATMMAPTTDP1 | |
| SCHEMBL31429944 | 0.76 | MEN1 (0.51) | MEN1KMT2AATMMAPTTDP1 | |
| SCHEMBL28774865 | 0.71 | HCAR1 (0.36) | — | |
| SCHEMBL28436430 | 0.65 | MAPT (0.40) | MAPTTDP1L3MBTL1KDM4EMAPK1 | |
| SCHEMBL570426 | 0.64 | USP30 (0.39) | MEN1KMT2AMAPTL3MBTL1MAPK1 | |
| SCHEMBL28523211 | 0.63 | KMT2A (0.47) | MEN1KMT2AMAPTKDM4EPRKCZ | |
| SCHEMBL28433432 | 0.62 | MAPT (0.38) | MEN1KMT2AATMMAPTL3MBTL1 | |
| SCHEMBL11064855 | 0.61 | MEN1 (0.54) | MEN1KMT2AATMMAPTTDP1 | |
| SCHEMBL23064587 | 0.61 | FFAR1 (0.46) | KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101243050-B | Pyrazolone derivatives | HOFFMANN LA ROCHE | 2012-07-04 | — | — | CN | disclosed |
| CN-101243050-A | Pyrazolone derivatives | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | disclosed |