⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29350921 | 0.80 | ALDH1A1 (0.38) | — | |
| SCHEMBL217939 | 0.80 | ALDH1A1 (0.38) | — | |
| SCHEMBL5679719 | 0.74 | — | — | |
| Pyrazine SCHEMBL27517504 | 0.72 | ALDH1A1 (0.43) | — | |
| SCHEMBL29460954 | 0.70 | — | — | |
| SCHEMBL136280 | 0.70 | — | — | |
| SCHEMBL27835683 | 0.70 | ALDH1A1 (0.39) | — | |
| SCHEMBL7939455 | 0.70 | — | — | |
| SCHEMBL22876719 | 0.70 | — | — | |
| SCHEMBL12389423 | 0.70 | NOS3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023278-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZINE COMPOUNDS | Abbott Laboratories (US) | 2000-08-02 | — | — | EP | claimed |
| WO-1999019314-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZINE COMPOUNDS | ABBOTT LABORATORIES (US) | 1999-04-22 | — | — | WO | claimed |
| EP-0399856-B1 | Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them | LIPHA (FR) | 1995-08-09 | — | — | EP | claimed |
| EP-0399856-A1 | Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1990-11-28 | — | — | EP | claimed |
| EP-4532486-A1 | PYRIDINE CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | Boundless Bio, Inc. (US) | 2025-04-09 | — | — | EP | disclosed |
| EP-4396191-A1 | COMPOUNDS USEFUL IN MODULATION OF AHR SIGNALLING | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023033740-A9 | COMPOUNDS USEFUL IN MODULATION OF AHR SIGNALLING | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2023-12-28 | — | — | WO | disclosed |
| US-11844854-B2 | Fragrance materials | THE PROCTER & GAMBLE COMPANY (US) | 2023-12-19 | — | — | US | disclosed |
| CN-111995591-B | Dicyanopyrazine compound, light-emitting material, and light-emitting element using same | 国立大学法人九州大学 | 2023-12-08 | — | — | CN | disclosed |
| CN-111995589-B | Process for producing 2, 5-dicyano-3, 6-dihalopyrazine | 国立大学法人九州大学 | 2023-12-05 | — | — | CN | disclosed |
| WO-2023230477-A1 | PYRIDINE CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | BOUNDLESS BIO, INC. (US) | 2023-11-30 | — | — | WO | disclosed |
| WO-2023033740-A1 | COMPOUNDS USEFUL IN MODULATION OF AHR SIGNALLING | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2023-03-09 | — | — | WO | disclosed |
| EP-0132577-A1 | Colour-photographic recording material with a dye releaser for blue-green dyestuffs, a colour image obtained with these dyestuffs and the dyestuffs themselves | Agfa-Gevaert AG (DE) | 1985-02-13 | — | — | EP | disclosed |
| EP-0048001-B1 | METHOD FOR PREPARING N-(4-(((2,4-DIAMINO-6-PTERIDINYL)-METHYL)METHYLAMINO)BENZOYL)GLUTAMIC ACID | Farmos Group Ltd. (FI) | 1984-12-19 | — | — | EP | disclosed |
| EP-0048001-A1 | Method for preparing N-(4-(((2,4-diamino-6-pteridinyl)-methyl)methylamino)benzoyl)glutamic acid | Farmos Group Ltd. (FI) | 1982-03-24 | — | — | EP | disclosed |
| US-4112094-A | ANTIALLERGENS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1978-09-05 | — | — | US | disclosed |
| US-4079056-A | REACTING 2,4-DIAMINO-6-PTERIDINE-METHANOL-HBR WITH TRIPHENYLPHOSPHINE DIBROMIDE OR PHOSPHORUS TRIBROMIDE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1978-03-14 | — | — | US | disclosed |
| US-4077957-A | INTERMEDIATE FOR METHOTREXATE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1978-03-07 | — | — | US | disclosed |
| US-3954753-A | SEDATIVES, MUSCLE RELAXANTS, ANTICONVULSANTS | HOFFMANN-LA ROCHE INC. (US) | 1976-05-04 | — | — | US | disclosed |
| US-3932404-A | REACTION WITH AMMONIA AND A BASIC AGENT | PECHINEY UGINE KUHLMANN (FR) | 1976-01-13 | — | — | US | disclosed |