Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143702 | 0.81 | CASR (0.70) | CASRSMN1; SMN2ALDH1A1HSD17B10POLB | |
| SCHEMBL13851579 | 0.78 | CASR (0.61) | CASRSMN1; SMN2ALDH1A1HSD17B10POLB | |
| SCHEMBL13602156 | 0.74 | CASR (0.47) | CASRPDE4BSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL5027393 | 0.74 | CASR (0.51) | CASRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5098015 | 0.71 | CASR (0.57) | CASRSMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL8799962 | 0.70 | TAAR1 (0.50) | SMN1; SMN2ALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL3380715 | 0.66 | CASR (1.00) | CASR | |
| SCHEMBL14601418 | 0.64 | JAK2 (0.42) | PDE4BPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4151611 | 0.64 | CASR (0.70) | CASRSMN1; SMN2ALDH1A1POLBRAB9A | |
| SCHEMBL9570485 | 0.64 | GPR84 (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101360498-A | Calcilytic compounds | SMITHKLINE BEECHAM CORP (US) | 2009-02-04 | — | — | CN | disclosed |